| Clinics and Pathology |
| Disease | rare type of acute myeloid leukemia |
| Phenotype / cell stem origin | basophilic precursor |
| Epidemiology | very rare but might be prominent in infants |
| Clinics | hyperhistaminemia syndrome has been reported in some of the cases |
| Cytology | major component of undifferentiated blasts + minor component of basophilic blasts (blasts containing large granules reacting positively to toluidine blue staining). |
| Treatment | ANLL protocols |
| Prognosis | good response to standard therapy for chilhood ANLL |
| Cytogenetics |
| Cytogenetics Morphological | t(X;6)(p11;q23) |
| Cytogenetics Molecular | not done |
| Genes involved and Proteins |
| Note | are unknown |
| External links |
| Other database | t(X;6)(p11;q23) | Mitelman database (CGAP - NCBI) | |
| Other database | t(X;6)(p11;q23) | CancerChromosomes (NCBI) |
| Bibliography |
| Acute basophilic leukaemia and translocation t(X;6)(p11;q23). |
| Dastugue N, Duchayne E, Kuhlein E, Rubie H, Demur C, Aurich J, Robert A, Sie P |
| British journal of haematology. 1997 ; 98 (1) : 170-176. |
| PMID 9233581 |
| Contributor(s) |
| Written | 02-1998 | Nicole Dastugue |
| Génétique des Hémopathies, Laboratoire d'Hématologie, Hôpital PURPAN, 31059 TOULOUSE CEDEX, France |
| Citation |
| This paper should be referenced as such : |
| Dastugue N . Acute basophilic leukemia; t(X;6)(p11;q23). Atlas Genet Cytogenet Oncol Haematol. February 1998 . URL : http://AtlasGeneticsOncology.org/Genes/LAbaso1124.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Jul 14 16:31:59 2008 |
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