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TAL1 (1p32) deletion in lymphoid malignancies

Written2019-07Lubomir Mitev, Liliya Grahlyova
Military Medical Academy, Department of Cytogenetics and Molecular Biology, Sofia, Bulgaria,

Abstract Review on TAL1 deletion in lymphoid malignancies with data on clinics.

Keywords TAL1; STIL; SIL; T-cell lymphoblastic leukemia; B-cell lymphoblastic leukemia; Follicular lymphoma; Diffuse large B-cell lymphoma; Multiple myeloma; Plasma cell leukemia; Hodgkin lymphoma; Anaplastic large cell lymphoma; Adult T-cell leukemia/lymphoma

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ICD-Topo C420,C421,C424
ICD-Morpho 9837/3 T lymphoblastic leukaemia/lymphoma
ICD-Morpho 9836/3
ICD-Morpho 9690/3 Follicular lymphoma; Paediatric follicular lymphoma
ICD-Morpho 9680/3 Diffuse large B-cell lymphoma (DLBCL), NOS; Primary DLBCL of the CNS; Primary cutaneous DLBCL, leg type; EBV positive DLBCL of the elderly; DLBCL associated with chronic inflammation; B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma
ICD-Morpho 9732/3 Plasma cell myeloma / Multiple myeloma
ICD-Morpho 9733/3
ICD-Morpho 9650/3 Classical Hodgkin lymphoma
ICD-Morpho 9714/3 Anaplastic large cell lymphoma, ALK positive
ICD-Morpho 9827/3 Adult T-cell leukaemia/lymphoma
Atlas_Id 1808
Note The deletion of the TAL 1 gene may be due to the deletion of the band 1p32 (del(1)(p32)) or to a submicroscopic interstitial deletion between the TAL1 and STIL genes (Note: STIL is better known as "SIL"). The pathogenesis of the two deletions is different. The 1p32 deletion is probably related to the inactivation of a tumor suppressor gene or genes localized in the band 1p32, while the SIL-TAL1 deletion to deregulation of the TAL1 gene. Del(1)(p32) is found in a variety of B or T lymphoid malignances and the SIL-TAL1 deletion is associated only with T-acute lymphoblastic leukemia (ALL). Until now 39 cases with del(1)(p32) have been reported: 9 cases with acute lymphoblastic leukemia/lymphoblastic lymphoma, 2 cases with adult T-cell lymphoma/ leukemia (HTLV-1+), 8 cases with follicular lymphoma, 6 cases with diffuse large B-cell lymphoma, 3 cases with anaplastic large cell lymphoma, 2 cases with Hodgkin disease, 7 cases with multiple myeloma and 2 cases with plasma cell leukemia. The 1p32 deletion can be detected by conventional cytogenetics, and the SIL-TAL1 deletion by fluorescence in situ hybridization, Southern blot analysis and real time PCR.

Clinics and Pathology

Disease Deletion of band 1p32

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL)
Epidemiology The deletion is found in 9 cases ALL - 0.08% of all ALL cases with an abnormal karyotype: 3 cases with T-ALL (Schoch et al, 1996; Jarosova et al, 2016), 5 cases with B-ALL (Kristofferson et al, 1985; Pui et al, 1990; Pui et al, 1992; Ivanov Ofverholm et al, 2016) and 1 case without data on the cell phenotype (Prigogina et al, 1988). The patients with T-cell phenotype are males. The sex ratio of the cases with B-cell phenotype is M:F=1.5:1. The average age is 22.1 year (range 2-74).
Cytogenetics In six cases del(1)(q32) are with complex predominantly di- or hyperdiploid karyotypes. In two cases 1p32 deletion is accompanied with a second anomaly; one case with a T-cell phenotype has t(8;14)(q24;q11) and another with a B-cell phenotype del(12)(p12). In three cases the deletion is presented as additional deleted chromosome 1.

Disease Follicular lymphoma (FL)
Epidemiology The 1p32 deletion is described in 8 cases - 0.53% of all FL cases with an abnormal karyotype) (Yunis et al, 1984; Gaunt et al, 1986; Offit et al, 1989; Goyns et al, 1993; Wiodarska et al, 1994; Horsman et al, 2001; Aamot et al, 2007). The sex ratio is M:F=1:1.7 The average age is 51.2 year (range 43-62) (the age of 5 cases is reported).
Cytogenetics The cases are presented predominantly with highly complex di- or hyperdiploid karyotypes. In 7 cases the 1p32 deletion is associated with t(14;18)(q32;q21). In four cases the anomaly is accompanied with structural aberration of chromosome 6.

Disease Diffuse large B-cell lymphoma (DBCL)
Epidemiology Six cases are reported - 0.42% of all DBCL cases with an abnormal karyotype (Fukuhara et al, 1983; Ebrahim et al 1990; Weisenburger et al, 1996; Ichinohasama et al, 2000; Fan & Rizkalla, 2003; Kaneko et al, 2011). The sex ratio is M:F=2:1. The average age is 51.5 year (range 36-65) (the age of 4 cases is reported).
Cytogenetics The reported cases are predominantly with highly complex hyperdiploid or hypertetraploid karyotypes. In four cases the 1p32 deletion is associated with structural anomalies affecting 3q including the BCL6 locus 3q27. In three cases are found T-lineage anomalies - 14q11 rearrangements in two cases and t(2;5)(p23;q35) in one case and in two the B-lineage anomalies - 14q32 rearrangements.

Disease Multiple myeloma (MM)
Epidemiology Seven cases are described - 0.37% of all MM cases with an abnormal karyotype (Lewis & MacKenzie, 1984; Dewalt et al, 1985; Seong et al, 1998; Weinlander et al, 1998; Lioveras et al, 2004; Wu et al, 2007). The sex ratio is M:F=0.8:1. Age is reported in two cases - 67 and 73 years.
Cytogenetics All cases are with complex karyotypes. Three have hyperdiploid, one hypertetraploid, one pseudodiploid, and two hypodiploid karyotypes. In two cases an additional 1p32 deletion is found. In four cases the anomaly is associated with other structural rearrangements of chromosome 1. Only in one case 14q32 rearrangement is described.
Prognosis 1p32 deletion is major negative prognostic factor for progression free survival and overall survival in the cases with MM (Hebraud B et al, 2014).

Disease Plasma cell leukemia (PCL)
Cytogenetics Two cases (males; one 70 year old) are reported - 1.32% of all PCL cases with an abnormal karyotype (Lewis & MacKenzie, 1984; Colovic et al, 2008). Both cases have a complex karyotype (one hypodiploid and another hyperdiplod with 14q32 rearrangement).

Disease Hodgkin disease (HD)
Cytogenetics Two cases are reported (males, 52 and 76 years old) - 3.8% of all HD cases with an abnormal karyotype (Schlegelberger et al, 1994; Busson-Le Coniat et al, 1996). One is with an additional 1p32 deletion and another with a highly complex hyperdiploid karyotype carrying additional structural anomalies of chromosome 1. Both cases are with deletions of 6q.

Disease Anaplastic large cell lymphoma (ALCL)
Epidemiology Three cases are reported (two males and one female; 24, 40 and 52 years old) - 2.0% of all ALCL cases with an abnormal karyotype (Ebrahim et al, 1990; Falzetti et al, 1999; Colleoni et al, 2000). Two of them are with a T-cell phenotype.
Cytogenetics The three cases are with a complex karyotype. In one t(2;5)(p23;q35) is found and is associated with an additional 1p32 deletion and in another two copies of add(2)(p23). In all three cases the 1p32 deletion is accompanied with structural anomalies of chromosome 8, two of them with i(8)(q10).

Disease Adult T-cell lymphoma/leukemia (HTLV+) (ATCL)
Cytogenetics Two cases with a complex karyotype are reported (males; 58 and 68 years old) - 0.75% of all ATCL cases with an abnormal karyotype (Sadamory et al, 1986; Sadamory et al, 1991). In one the 1p32 deletion is presented as an additional anomaly. Both cases have structural aberrations involving chromosome 4.

Disease SIL-TAL1 deletion

Disease T- Acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL)
Phenotype / cell stem origin Is restricted to TCR of the alpha, beta and TCR delta lineage with a deletion of one or both alleles of the TCR delta gene (Breit et al, 1993a). TAL1 expression appeared to reflect the cortical stage of thymocyte development (late double positive stage) (Ferrando AA et al, 1992).
Etiology SIL-TAL1 deletion is mediated via illegitimate V(D)J recombination processes of T-cell receptor (TCR) gene (Aplan PD et al, 1990b).
Epidemiology SIL-TAL1 deletion is observed in 3-26 % of cases with T-ALL (Aplan et al, 1990b; Brown et al, 1990). The anomaly is more frequent in males (D'Angio M et al, 2014).
Clinics SIL-TAL1 deletion is associated with higher initial WBC count, T-lineage immunophenotype with CD2 expression, predominant cortical T-phenotype, low incidence in adult patients and higher frequency of extramedullary relapse (Bash RO et al, 1993; Stock W et al, 1995; Mansur MB et al, 2009; D'Angio M et al, 2014). Increased risk from developing of tumor lysis syndrome and disseminated intravascular coagulation were also reported (Wang D et al, 2013).
Cytogenetics SIL-TAL1 deletion represents a submicroscopic deletion of 90 Kb that affected all coding SIL exons. As a result of the deletion the first coding exons of TAL1 gene is juxtaposed to the promotor of SIL gene, causing its abnormal expression (Chen Q et al, 1990b; Aplan PD et al, 1992b). The breakpoint in SIL gene remains constant while several breakpoints of the TAL1 gene have been identified, which leads to formation of two main (TAL1d1 and TAL1d2 in 95% of the cases) and several rare types of SIL-TAL1 deletions (Breit et al, 1993a). Almost half of the cases with SIL-TAL1 deletion have normal karyotypes. The rest of the cases are presented with hyperdiploid and more frequently with pseudodiploid karyotypes associated with the structural anomalies del(6q) (7 cases), t(11;14)(p13;q11.2)/ t(11;14)(p15;q11.2) (3 cases) and t(8;14)(q24;q11.2) (1 case) (Wang Q et al, 2014; Cocce MC et al, 2015).
Prognosis The data on the prognosis of the cases with SIL-TAL1 deletion are controversial. Mansur MB et al. (2009) reported negative impact on the patients, while no difference in survival and overall outcome were seen by D'Angio M et al. (2014).


Using chromatin immunoprecipitation sequencing and chromosome conformation capture techniques, several scientific groups presented looping models for TAL1 expression in human and murine cell lines and described multiple interactions between TAL1 and their cis-acting regulatory elements (1a and 1b TAL1 promotors, enhancers and CTCF bound elements) (Zhou Y et al, 2013; Lai F et al, 2013; Patel B et al, 2013). Zhou Y et al. (2013) find in TAL1 expressing cell lines that the regulatory hubs which control transcription bring the TAL/SIL common breakpoint regions (TALd) into close proximity. The authors suggest that the physical proximity between these regions in the committed lymphoid cells may predispose to SIL-TAL1 deletion. However, the question remains: what is the reason that led to the rearrangement of the located in close proximity breakpoint regions? It should be noted that TAL1 gene is not expressed in the dividing double positive thymocytes, but SIL gene is expressed. In addition, the deletion primarily affects the SIL gene (all coding exons are deleted), so it can be assumed that the consequence of SIL-TAL1 deletion is not only deregulation of the TAL1 gene, but also inactivation of the SIL gene. These considerations suggest that the generation of SIL-TAL1 deletion is possibly due to a defective inactivation of the SIL gene which is intended to block the G2/M transition (through impairing the spindle assembly) and is a part of the complex mechanisms that induced the apoptosis during thymocyte negative selection. In this regard, future studies of looping patterns searching to discover the possible interactions leading to suppression of the SIL gene will elucidate the mechanisms of the formation of the SIL-TAL1 deletion as well as the role of the SIL gene in the regulation of the thymocyte apoptosis.

Genes involved and Proteins

Gene NameSTIL
Location 1p33
Note STIL (or SIL: SCL interrupting locus) gene extended over 70 Kb and contained 18 exons. The gene encodes a large (150 kDa) cytosolic protein implicated in regulation of the mitotic spindle checkpoint. It is required for the procentriole assembly and the regulation of the centriole duplication. SIL mRNA expression is higher in rapidly proliferating cells and decreased rapidly during terminal differentiation. It is a positive regulator of the sonic hedgehog pathway and plays an important role in embryonic development. It is over expressed in multiple types of cancer and its expression correlates with the expression of mitotic checkpoint.
Gene NameTAL1
Location 1p33
Note TAL1 (T-cell acute leukemia 1) is a member of the class II helix-loop-helix (bHLH) family of transcription factors. The gene extended over 16 Kb and contained 6 exons. Have two isoforms: a long TAL1 (L) and short TAL1 (S). After heterodimerization with members of the class I bHLH proteins known as E proteins ( TCF3 (E2A), TCF12 (HEB), BHLHE22 (E2-2)), it binds E-box motif and forms complex with other transcription factors, including LMO, GATA1, RUNX1 and LDB1. TALl1 is expressed in hematopoietic stem cells, progenitor cells and erythro-megakaryocyte lineage. It is required for the specification of the haemangioblasts and the blood cell lineages and also plays a key role for the maturation of the megakaryocytes and erythroblasts (Porcher C et al, 1996; Porcher C et al, 2017; Gering M et al, 1998; Schlaeger TM et al, 2005). TAL1 is transcriptionally silenced during normal lymphocyte development including at the stage of CD4+ CD8+ double-positive thymocytes (the stage of maturation arrest of TAL1 positive T-ALL) (Tremblay M et al, 2010; Seita J et al, 2012). The transcriptional targets of the TAL1 in the normal hematopoietic cells are KIT, CDKN1A, DDIT4, KLF1, EPB42, GYPA, UBE2H and MEF2C (Lecuyer E et al, 2002; Lacombe J et al, 2010; Benyoucef A et al, 2015; Kassouf MT et al, 2010; Xu Z et al, 2003). As part of the highly interconnected auto-regulated circuit, it controls the transcription factors LMO2, RUNX2, MYB and GATA2. Except through a SIL-TAL1 deletion, TAL1 deregulation occurs also as a result of the chromosome translocations t(1;14)(p32;q11) and t(1;7)(p32;q34) and through its ectopic expression (60% of the cases) (Ferrando AA et al, 2002). Recently another mechanism oduces a binding motif for MYB transcription factor (Mansour MR et al, 2014). Deregulation of TAL1 inhibits E-proteins heterodimerization leading to block of T-cell differentiation. However, the oncogenic role of TAL1 in T-cell transformation is more complex and is linked to their influence on the function of the core regulatory circuitry (Sanda T et al, 2012) as well as on multiple downstream targets including ARID5B, NKX3-1, MYCN, CDKN2A, ALDH1A2 and MIR223 (Leong WZ et al, 2017; Kusy S et al, 2010; Astolfi A et al, 2014; Hansson A et al, 2003; Ono Y et al, 1998; Mansour MR et al, 2013).


Non-Hodgkin lymphoma with t(14;18): clonal evolution patterns and cytogenetic-pathologic-clinical correlations.
Aamot HV, Torlakovic EE, Eide MB, Holte H, Heim S.
J Cancer Res Clin Oncol. 2007 Jul;133(7):455-70. Epub 2007 Jan 18.
PMID 17235551
Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.
Aplan PD, Lombardi DP, Reaman GH, Sather HN, Hammond GD, Kirsch IR.
Blood. 1992 Mar 1;79(5):1327-33.
PMID 1311214
MYCN is a novel oncogenic target in pediatric T-cell acute lymphoblastic leukemia.
Astolfi A, Vendemini F, Urbini M, Melchionda F, Masetti R, Franzoni M, Libri V, Serravalle S, Togni M, Paone G, Montemurro L, Bressanin D, Chiarini F, Martelli AM, Tonelli R, Pession A.
Oncotarget. 2014 Jan 15;5(1):120-30.
PMID 24334727
Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study.
Bash RO, Crist WM, Shuster JJ, Link MP, Amylon M, Pullen J, Carroll AJ, Buchanan GR, Smith RG, Baer R.
Blood. 1993 Apr 15;81(8):2110-7.
PMID 8471769
The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells.
Benyoucef A, Calvo J, Renou L, Arcangeli ML, van den Heuvel A, Amsellem S, Mehrpour M, Larghero J, Soler E, Naguibneva I, Pflumio F.
Stem Cells. 2015 Jul;33(7):2268-79. doi: 10.1002/stem.2028. Epub 2015 May 25
PMID 25858676
Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes.
Breit TM1, Mol EJ, Wolvers-Tettero IL, Ludwig WD, van Wering ER, van Dongen JJ.
J Exp Med. 1993 Apr 1;177(4):965-77.
PMID 8459224
Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia.
Brown L, Cheng JT, Chen Q, Siciliano MJ, Crist W, Buchanan G, Baer R.
EMBO J. 1990 Oct;9(10):3343-51.
PMID 2209547
Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations.
Busson-Le Coniat M1, Salomon-Nguyen F, Dastugue N, Maarek O, Lafage-Pochitaloff M, Mozziconacci MJ, Baranger L, Brizard F, Radford I, Jeanpierre M, Bernard OA, Berger R.
Leukemia. 1999 Dec;13(12):1975-81
PMID 10602418
Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.
Chen Q, Yang CY, Tsan JT, Xia Y, Ragab AH, Peiper SC, Carroll A, Baer R.
J Exp Med. 1990 Nov 1;172(5):1403-8.
PMID 2230650
Cytogenetic and Molecular Findings in Children with Acute Lymphoblastic Leukemia: Experience of a Single Institution in Argentina.
Coccé M C, Alonso C N, Rossi J G, Bernasconi A R, Rampazzi M A, Felice M S, Rubio P L, Eberle S E, Medina A, Gallego M S.
Mol Syndromol. 2015 Oct; 6(4): 193-203. Published online 2015 Oct 7. doi: 10.1159/000441046
PMID 26648836
ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35).
Colleoni GW, Bridge JA, Garicochea B, Liu J, Filippa DA, Ladanyi M.
Am J Pathol. 2000 Mar;156(3):781-9.
PMID 10702393
Thirty patients with primary plasma cell leukemia: a single center experience.
Colovi? M, Jankovi? G, Suvajdzi? N, Mili? N, Dordevi? V, Jankovi? S.
Med Oncol. 2008;25(2):154-60. doi: 10.1007/s12032-007-9011-5. Epub 2007 Oct 10.
PMID 18488157
Clinical features and outcome of SIL/TAL1-positive T-cell acute lymphoblastic leukemia in children and adolescents: a 10-year experience of the AIEOP group.
D'Angi M, Valsecchi MG, Testi AM, Conter V, Nunes V, Parasole R, Colombini A, Santoro N, Varotto S, Caniglia M, Silvestri D, Consarino C, Levati L, Magrin E, Locatelli F, Basso G, Foà R, Biondi A, Cazzaniga G.
Haematologica. 2015 Jan;100(1):e10-3. doi:10.3324/haematol. 2014.112151.Epub 2014 Oct 10.
PMID 25304610
The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis.
Dewald GW, Kyle RA, Hicks GA, Greipp PR.
Blood. 1985 Aug;66(2):380-90.
PMID 3926026
Immunohistochemical, molecular, and cytogenetic analysis of a consecutive series of 20 peripheral T-cell lymphomas and lymphomas of uncertain lineage, including 12 Ki-1 positive lymphomas.
Ebrahim SA, Ladanyi M, Desai SB, Offit K, Jhanwar SC, Filippa DA, Lieberman PH, Chaganti RS.
Genes Chromosomes Cancer. 1990 May;2(1):27-35.
PMID 2177640
Genomic instability and recurrent breakpoints are main cytogenetic findings in Hodgkin's disease.
Falzetti D, Crescenzi B, Matteuci C, Falini B, Martelli MF, Van Den Berghe H, Mecucci C.
Haematologica. 1999 Apr;84(4):298-305.
PMID 10190942
Comprehensive cytogenetic analysis including multicolor spectral karyotyping and interphase fluorescence in situ hybridization in lymphoma diagnosis. a summary of 154 cases.
Fan YS and Rizkalla K.
Cancer Genet Cytogenet. 2003 May;143(1):73-9
PMID 12742158
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.
Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, Lander ES, Golub TR, Look AT.
Cancer Cell. 2002 Feb;1(1):75-87.
PMID 12086890
Cytogenetic approaches to the clarification of pathogenesis in lymphoid malignancies: clinicopathologic characterization of 14q+ marker-positive non-T-cell malignancies.
Fukuhara S, Nasu K, Kita K, Ueshima Y, Oguma S, Yamabe H, Nishigori M, Uchino H.
Jpn J Clin Oncol. 1983 Sep;13(3):461-75.
PMID 6580474
Karyotype abnormalities in non-Hodgkin lymphomas.
Gaunt KL, Callaghan J, Roberts DF.
Ann Genet. 1986;29(2):82-7.
PMID 3490211
The SCL gene specifies haemangioblast development from early mesoderm.
Gering M, Rodaway A R, Göttgens B, Patient R K, Green A R.
EMBO J. 1998 Jul 15; 17(14): 4029-4045.doi: 10.1093/emboj/17.14.4029
PMID 9670018
Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma.
Goyns MH, Hammond DW, Harrison CJ, Menasce LP, Ross FM, Hancock BW.
Leukemia. 1993 Jun;7(6):848-52.
PMID 8501979
The basic helix-loop-helix transcription factor TAL1/SCL inhibits the expression of the p16INK4A and pTalpha genes.
Hansson A, Manetopoulos C, Jönsson JI, Axelson H.
Biochem Biophys Res Commun. 2003 Dec 26;312(4):1073-81.
PMID 14651981
Deletion of the 1p32 region is a major independent prognostic factor in young patients with myeloma: the IFM experience on 1195 patients.
Hebraud B, Leleu X, Lauwers-Cances V, Roussel M, Caillot D, Marit G, Karlin L, Hulin C, Gentil C, Guilhot F, Garderet L, Lamy T, Brechignac S, Pegourie B, Jaubert J, Dib M, Stoppa AM, Sebban C, Fohrer C, Fontan J, Fruchart C, Macro M, Orsini-Piocelle F, Lepeu G, Sohn C, Corre J, Facon T, Moreau P, Attal M, Avet-Loiseau H.
Leukemia. 2014 Mar;28(3):675-9. doi: 10.1038/leu.2013.225. Epub 2013 Jul 29.
PMID 23892719
Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18).
Horsman DE, Connors JM, Pantzar T, Gascoyne RD.
Genes Chromosomes Cancer. 2001 Apr;30(4):375-82.
PMID 11241790
Ph-negative non-Hodgkin's lymphoma occurring in chronic phase of Ph-positive chronic myelogenous leukemia is defined as a genetically different neoplasm from extramedullary localized blast crisis: report of two cases and review of the literature.
Ichinohasama R, Miura I, Takahashi N, Sugawara T, Tamate E, Endoh K, Endoh F, Naganuma H, DeCoteau JF, Griffin JD, Kadin ME, Ooya K
Leukemia. 2000 Jan;14(1):169-82.
PMID 10637493
Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia.
Ivanov fverholm I, Tran AN, Olsson L, Zachariadis V, Heyman M, Rudd E, Syk Lundberg E, Nordenskjöld M, Johansson B, Nordgren A, Barbany G.
Leuk Lymphoma. 2016 Sep;57(9):2161-70. doi: 10.3109/10428194.2015.1136740. Epub 2016 Apr 19.
PMID 27090575
Chromosomal aberrations in childhood acute lymphoblastic leukemia: 15-year single center experience.
Jarosova M, Volejnikova J, Porizkova I, Holzerova M, Pospisilova D, Novak Z, Vrbkova J, Mihal V.
Cancer Genet. 2016 Jul-Aug;209(7-8):340-7. doi: 10.1016/j.cancergen.2016.06.004. Epub 2016 Jun 11.
PMID 27341996
Cytogenetic analysis of de novo CD5-positive diffuse large B-cell lymphoma.
Kaneko H, Shimura K, Horiike S, Kuroda J, Matsumoto Y, Yokota S, Nishida K, Ohkawara Y, Taniwaki M.
Asia Pac J Clin Oncol. 2011 Dec;7(4):346-50. doi: 10.1111/j.1743-7563.2011.01432.x
PMID 25151983
Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells.
Kassouf MT, Hughes JR, Taylor S, McGowan SJ, Soneji S, Green AL, Vyas P, Porcher C.
Genome Res. 2010 Aug;20(8):1064-83. doi: 10.1101/gr.104935.110. Epub 2010 Jun 21.
PMID 20566737
Cytogenetic studies in non-Hodgkin lymphomas--results from fine-needle aspiration samples.
Kristoffersson U, Olsson H, Akerman M, Mitelman F.
Hereditas. 1985;103(1):63-76.
PMID 4055413
NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia.
Kusy S, Gerby B, Goardon N, Gault N, Ferri F, Gérard D, Armstrong F, Ballerini P, Cayuela JM, Baruchel A, Pflumio F, Roméo PH
J Exp Med. 2010 Sep 27;207(10):2141-56. doi: 10.1084/jem.20100745. Epub 2010 Sep 20.
PMID 20855495
The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1.
Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T.
Blood. 2002 Oct 1;100(7):2430-40.
PMID 12239153
Scl regulates the quiescence and the long-term competence of hematopoietic stem cells.
Lacombe J, Herblot S, Rojas-Sutterlin S, Haman A, Barakat S, Iscove NN, Sauvageau G, Hoang T.
Blood. 2010 Jan 28;115(4):792-803. doi: 10.1182/blood-2009-01-201384. Epub 2009 Oct 22
PMID 19850742
Activating RNAs associate with Mediator to enhance chromatin architecture and transcription.
Lai F, Orom UA, Cesaroni M, Beringer M, Taatjes DJ, Blobel GA, Shiekhattar R.
Nature. 2013 Feb 28;494(7438):497-501. doi: 10.1038/nature11884. Epub 2013 Feb 17.
PMID 23417068
ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis.
Leong WZ, Tan SH, Ngoc PCT, Amanda S, Yam AWY, Liau WS, Gong Z, Lawton LN, Tenen DG, Sanda T.
Genes Dev. 2017 Dec 1;31(23-24):2343-2360. doi: 10.1101/gad.302646.117. Epub 2018 Jan 11.
PMID 29326336
Non-random chromosomal aberrations associated with multiple myeloma.
Lewis JP and MacKenzie MR.
Hematol Oncol. 1984 Oct-Dec;2(4):307-17.
PMID 6335483
Cytogenetic and fluorescence in situ hybridization studies in 60 patients with multiple myeloma and plasma cell leukemia.
Lloveras E, Granada I, Zamora L, Espinet B, Florensa L, Besses C, Xandri M, Pérez-Vila ME, Millà F, Woessner S, Solé F.
Cancer Genet Cytogenet. 2004 Jan 1;148(1):71-6.
PMID 14697644
Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.
Mansour MR, Abraham BJ, Anders L, Berezovskaya A, Gutierrez A, Durbin AD, Etchin J, Lawton L, Sallan SE, Silverman LB, Loh ML, Hunger SP, Sanda T, Young RA, Look AT.
Science. 2014 Dec 12;346(6215):1373-7. doi: 10.1126/science.1259037. Epub 2014 Nov 13.
PMID 25394790
SIL-TAL1 fusion gene negative impact in T-cell acute lymphoblastic leukemia outcome.
Mansur MB, Emerenciano M, Brewer L, Sant'Ana M, Mendonça N, Thuler LC, Koifman S, Pombo-de-Oliveira MS.
Leuk Lymphoma. 2009 Aug;50(8):1318-25. doi: 10.1080/10428190903040014.
PMID 19562638
Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer (2019).
Mitelman F, Johansson B and Mertens F (Eds.)
t(3;22)(q27;q11): a novel translocation associated with diffuse non-Hodgkin's lymphoma.
Offit K, Jhanwar S, Ebrahim SA, Filippa D, Clarkson BD, Chaganti RS.
Blood. 1989 Nov 1;74(6):1876-9.
PMID 2804338
TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3.
Ono Y, Fukuhara N, Yoshie O.
Mol Cell Biol. 1998 Dec;18(12):6939-50.
PMID 9819382
Aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia.
Patel B, Kang Y, Cui K, Litt M, Riberio MS, Deng C, Salz T, Casada S, Fu X, Qiu Y, Zhao K, Huang S.
Leukemia. 2014 Feb;28(2):349-61. doi: 10.1038/leu.2013.158. Epub 2013 May 23.
PMID 23698277
SCL/TAL1: a multifaceted regulator from blood development to disease.
Porcher C, Chagraoui H, Kristiansen MS.
Blood. 2017 Apr 13;129(15):2051-2060. doi: 10.1182/blood-2016-12-754051. Epub 2017 Feb 8.
PMID 28179281
The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.
Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH.
Cell. 1996 Jul 12;86(1):47-57.
PMID 8689686
Nonrandom chromosomal abnormalities in acute lymphoblastic leukemia of childhood.
Prigogina EL, Puchkova GP, Mayakova SA.
Cancer Genet Cytogenet. 1988 Jun;32(2):183-203.
PMID 3163259
Isochromosomes in childhood acute lymphoblastic leukemia: a collaborative study of 83 cases.
Pui CH, Carroll AJ, Raimondi SC, Schell MJ, Head DR, Shuster JJ, Crist WM, Borowitz MJ, Link MP, Behm FG, et al.
Blood. 1992 May 1;79(9):2384-91.
PMID 1571550
Relationship between chromosomal breakpoint and molecular rearrangement of T-cell antigen receptors in adult T-cell leukaemia.
Sadamori N, Isobe M, Shimizu S, Yamamori T, Itoyama T, Ikeda S, Yamada Y, Ichimaru M.
Acta Haematol. 1991;86(1):14-9
PMID 1659101
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, Jamieson CH, Staudt LM, Young RA, Look AT.
Cancer Cell. 2012 Aug 14;22(2):209-21. doi: 10.1016/j.ccr.2012.06.007.
PMID 22897851
Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development.
Schlaeger TM, Mikkola HK, Gekas C, Helgadottir HB, Orkin SH.
Blood. 2005 May 15;105(10):3871-4. Epub 2005 Jan 27.
PMID 15677556
Cytogenetic findings and results of combined immunophenotyping and karyotyping in Hodgkin's disease.
Schlegelberger B, Weber-Matthiesen K, Himmler A, Bartels H, Sonnen R, Kuse R, Feller AC, Grote W.
Leukemia. 1994 Jan;8(1):72-80.
PMID 8289502
17p anomalies in lymphoid malignancies: diagnostic and prognostic implications.
Schoch C, Rieder H, Stollmann-Gibbels B, Freund M, Tischler HJ, Silling-Engelhardt G, Fonatsch C.
Leuk Lymphoma. 1995 Apr;17(3-4):271-9.
PMID 8580796
Gene Expression Commons: an open platform for absolute gene expression profiling.
Seita J, Sahoo D, Rossi DJ, Bhattacharya D, Serwold T, Inlay MA, Ehrlich LI, Fathman JW, Dill DL, Weissman IL.
PLoS One. 2012;7(7):e40321. doi: 10.1371/journal.pone.0040321. Epub 2012 Jul 18.
PMID 22815738
Prognostic value of cytogenetics in multiple myeloma.
Seong C, Delasalle K, Hayes K, Weber D, Dimopoulos M, Swantkowski J, Huh Y, Glassman A, Champlin R, Alexanian R.
Br J Haematol. 1998 Apr;101(1):189-94.
PMID 9576200
Low incidence of TAL1 gene rearrangements in adult acute lymphoblastic leukemia: A cancer and leukemia group B study (8762)
Stock W, Westbrook CA, Sher DA, Dodge R, Sobol RE, Wurster-Hill D, Davey FR, Larson RA, LeBeau MM, Aplan PD, Frankel SR, Stewart CC, Bloomfield CD.
Clin Cancer Res. 1995 Apr;1(4):459-63.
PMID 9816004
Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.
Tremblay M, Tremblay CS, Herblot S, Aplan PD, Hébert J, Perreault C, Hoang T.
Genes Dev. 2010 Jun 1;24(11):1093-105. doi: 10.1101/gad.1897910.
PMID 20516195
SIL-TAL1 Rearrangement is Related with Poor Outcome: A Study from a Chinese Institution.
Wang D, Zhu G, Wang |N, Zhou X, Yang Y, Zhou S, Xiong J, He J, Jiang L, Li C, Xu D, Huang L, Zhou J
PLoS One. 2013; 8(9): e73865.Published online 2013 Sep 9. doi: 10.1371/journal.pone.0073865
PMID 24040098
[Correlation between expression of SIL-TAL1 fusion gene and deletion of 6q in T-cell acute lymphoblastic leukemia].
Wang Q, Wu LL, Dai HP, Ping NN, Wu CX, Pan JL, Cen JN, Qiu HY, Chen SN.
PMID 25543465
Cytogenetic analysis and fluorescence in situ hybridization in a case of IgD multiple myeloma.
Weinländer G, Drach J, Raderer M, Okamoto I, Ackermann J, Stögermayer B, Fazeny B, Nowotny H, Marosi C.
Cancer Genet Cytogenet. 1998 Sep;105(2):172-6.
PMID 9723037
Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma.
Weisenburger DD, Gordon BG, Vose JM, Bast MA, Chan WC, Greiner TC, Anderson JR, Sanger WG.
Blood. 1996 May 1;87(9):3860-8.
PMID 8311713
t(1;19) without detectable E2A rearrangements in two t(14;18)-positive lymphoma/leukemia cases.
Wlodarska I, Stul M, De Wolf-Peeters C, Verhoef G, Mecucci C, Cassiman JJ, Van den Berghe H.
Genes Chromosomes Cancer. 1994 Jul;10(3):171-6.
PMID 7522039
Abnormalities of chromosome 1p/q are highly associated with chromosome 13/13q deletions and are an adverse prognostic factor for the outcome of high-dose chemotherapy in patients with multiple myeloma.
Wu KL, Beverloo B, Lokhorst HM, Segeren CM, van der Holt B, Steijaert MM, Westveer PH, Poddighe PJ, Verhoef GE, Sonneveld P; Dutch-Belgian Haemato-Oncology Cooperative Study Group (HOVON); Dutch Working Party on Cancer Genetics and Cytogenetics (NWCGC).
Br J Haematol. 2007 Feb;136(4):615-23.
PMID 17223915
Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation.
Xu Z1, Huang S, Chang LS, Agulnick AD, Brandt SJ.
Mol Cell Biol. 2003 Nov;23(21):7585-99.
PMID 14560005
Recurrent chromosomal defects are found in most patients with non-Hodgkin's-lymphoma.
Yunis JJ, Oken MM, Theologides A, Howe RB, Kaplan ME.
Cancer Genet Cytogenet. 1984 Sep;13(1):17-28.
PMID 6467179
Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL.
Zhou Y, Kurukuti S, Saffrey P, Vukovic M, Michie AM, Strogantsev R, West AG, Vetrie D.
Blood. 2013 Dec 19;122(26):4199-209. doi: 10.1182/blood-2013-02-483875. Epub 2013 Nov 7.
PMID 24200685


This paper should be referenced as such :
Lubomir Mitev, Liliya Grahlyova
TAL1 (1p32) deletion in lymphoid malignancies
Atlas Genet Cytogenet Oncol Haematol. 2020;24(05):208-214.
Free journal version : [ pdf ]   [ DOI ]
On line version :

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