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dic(9;20)(p13;q11) PAX5/NOL4L

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3069

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NamePAX5
Location 9p13.2
Gene NameNOL4L
Location 20q11.21

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Clinical and cytogenetic features of pediatric dic(9;20)(p13
Forestier E, Gauffin F, Andersen MK, Autio K, Borgström G, Golovleva I, Gustafsson B, Heim S, Heinonen K, Heyman M, Hovland R, Johannsson JH, Kerndrup G, Rosenquist R, Schoumans J, Swolin B, Johansson B, Nordgren A; Nordic Society of Pediatric Hematology and Oncology; Swedish Cytogenetic Leukemia Study Group; NOPHO Leukemia Cytogenetic Study Group
2;q11 2)-positive B-cell precursor acute lymphoblastic leukemias: a Nordic series of 24 cases and review of the literature
PMID 17990329
 
Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray
Kawamata N, Ogawa S, Zimmermann M, Niebuhr B, Stocking C, Sanada M, Hemminki K, Yamatomo G, Nannya Y, Koehler R, Flohr T, Miller CW, Harbott J, Ludwig WD, Stanulla M, Schrappe M, Bartram CR, Koeffler HP
Proc Natl Acad Sci U S A 2008 Aug 19;105(33):11921-6
PMID 18697940
 
Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer
An Q, Wright SL, Konn ZJ, Matheson E, Minto L, Moorman AV, Parker H, Griffiths M, Ross FM, Davies T, Hall AG, Harrison CJ, Irving JA, Strefford JC
Proc Natl Acad Sci U S A 2008 Nov 4;105(44):17050-4
PMID 18957548
 
Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11
An Q, Wright SL, Moorman AV, Parker H, Griffiths M, Ross FM, Davies T, Harrison CJ, Strefford JC
21 Haematologica
PMID 19586940
 
Prognostic relevance of dic(9;20)(p11;q13) in childhood B-cell precursor acute lymphoblastic leukaemia treated with Berlin-Frankfurt-Münster (BFM) protocols containing an intensive induction and post-induction consolidation therapy
Pichler H, Möricke A, Mann G, Teigler-Schlegel A, Niggli F, Nebral K, König M, Inthal A, Krehan D, Dworzak MN, Janousek D, Harbott J, Schrappe M, Gadner H, Strehl S, Haas OA, Panzer-Grümayer R, Attarbaschi A; Berlin-Frankfurt-Münster (BFM) Study Group
Br J Haematol 2010 Apr;149(1):93-100
PMID 20067563
 
The frequency and prognostic impact of dic(9;20)(p13
Zachariadis V, Gauffin F, Kuchinskaya E, Heyman M, Schoumans J, Blennow E, Gustafsson B, Barbany G, Golovleva I, Ehrencrona H, Cavelier L, Palmqvist L, Lönnerholm G, Nordenskjöld M, Johansson B, Forestier E, Nordgren A; Nordic Society of Pediatric Hematology, Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG)
2;q11 2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial
PMID 21242996
 


Translocations implicated (Data extracted from papers in the Atlas)

 dic(9;20)(p13;q11) PAX5/NOL4L

External links

PAX5 (9p13.2) NOL4L (20q11.21)

Mitelman databasedic(9;20)(p13;q11) [Case List]    dic(9;20)(p13;q11) [Transloc-MCList] PAX5/NOL4L [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:20:26 CET 2018


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