Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ins(4;11)(q21;q23q23) ATG16L2/KMT2A

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 2532

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameATG16L2
Location 11q13.4
Gene NameKMT2A
Location 11q23.3

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute


Cryptic insertion and translocation or nondividing leukemic cells disclosed by FISH analysis in infant acute leukemia with discrepant molecular and cytogenetic findings
Watanabe N, Kobayashi H, Ichiji O, Yoshida MA, Kikuta A, Komada Y, Sekine I, Ishida Y, Horiukoshi Y, Tsunematsu Y, Yano M, Nakadate H, Kaneko Y
Leukemia 2003 May;17(5):876-82
PMID 12750700
Insertion of chromosome 11 in chromosome 4 resulting in a 5'MLL-3'AF4 fusion gene in a case of adult acute lymphoblastic leukemia
Morel F, Le Bris MJ, Douet-Guilbert N, Duchemin J, Herry A, Le Calvez G, Marion V, Berthou C, De Braekeleer M
Cancer Genet Cytogenet 2003 Aug;145(1):74-7
PMID 12885467
Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4
Kowarz E, Burmeister T, Lo Nigro L, Jansen MW, Delabesse E, Klingebiel T, Dingermann T, Meyer C, Marschalek R
MLL fusion allele Leukemia
PMID 17410185
Identification of MLL partner genes in 27 patients with acute leukemia from a single cytogenetic laboratory
De Braekeleer E, Meyer C, Douet-Guilbert N, Basinko A, Le Bris MJ, Morel F, Berthou C, Marschalek R, Férec C, De Braekeleer M
Mol Oncol 2011 Dec;5(6):555-63
PMID 21900057

Translocations implicated (Data extracted from papers in the Atlas)

 ins(4;11)(q21;q23q23) ATG16L2/KMT2A

External links

ATG16L2 (11q13.4) KMT2A (11q23.3)

Mitelman databaseins(4;11)(q21;q23q23) [Case List]    ins(4;11)(q21;q23q23) [Transloc-MCList] ATG16L2/KMT2A [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Jan 10 17:20:28 CET 2018

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