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ins(4;11)(q21;q23q23) DSCAML1/KMT2A

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2665

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameDSCAML1
Location 11q23.3
Gene NameKMT2A
Location 11q23.3

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Cryptic insertion and translocation or nondividing leukemic cells disclosed by FISH analysis in infant acute leukemia with discrepant molecular and cytogenetic findings
Watanabe N, Kobayashi H, Ichiji O, Yoshida MA, Kikuta A, Komada Y, Sekine I, Ishida Y, Horiukoshi Y, Tsunematsu Y, Yano M, Nakadate H, Kaneko Y
Leukemia 2003 May;17(5):876-82
PMID 12750700
 
Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4
Kowarz E, Burmeister T, Lo Nigro L, Jansen MW, Delabesse E, Klingebiel T, Dingermann T, Meyer C, Marschalek R
MLL fusion allele Leukemia
PMID 17410185
 


Translocations implicated (Data extracted from papers in the Atlas)

 ins(4;11)(q21;q23q23) DSCAML1/KMT2A

External links

DSCAML1 (11q23.3) KMT2A (11q23.3)

Mitelman databaseins(4;11)(q21;q23q23) [Case List]    ins(4;11)(q21;q23q23) [Transloc-MCList] DSCAML1/KMT2A [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:20:28 CET 2018


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