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ins(10;11)(p12;q23q23) MLLT10/CLP1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 2963

Clinics and Pathology

Disease Acute monoblastic leukemia (FAB type M5)

Genes involved and Proteins

Gene NameMLLT10
Location 10p12.31
Gene NameCLP1
Location Xq22.3

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute


Cryptic rearrangement involving MLL and AF10 occurring in utero
Jones LK, Neat MJ, van Delft FW, Mitchell MP, Adamaki M, Stoneham SJ, Patel N, Saha V
Leukemia 2003 Aug;17(8):1667-9
PMID 12886258
Cryptic MLL-AF10 fusion caused by insertion of duplicated 5' part of MLL into 10p12 in acute leukemia: a case report
Jarosova M, Takacova S, Holzerova M, Priwitzerova M, Divoka M, Lakoma I, Mihal V, Indrak K, Divoky V
Cancer Genet Cytogenet 2005 Oct 15;162(2):179-82
PMID 16213369
AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12)
Tanabe S, Bohlander SK, Vignon CV, Espinosa R 3rd, Zhao N, Strissel PL, Zeleznik-Le NJ, Rowley JD
Blood 1996 Nov 1;88(9):3535-45
PMID 8896421

Translocations implicated (Data extracted from papers in the Atlas)

 ins(10;11)(p12;q23q23) MLLT10/CLP1

External links

MLLT10 (10p12.31) CLP1 (Xq22.3)

Mitelman databaseins(10;11)(p12;q23q23) [Case List]    ins(10;11)(p12;q23q23) [Transloc-MCList] MLLT10/CLP1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Fri Feb 23 20:22:47 CET 2018

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