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ins(15;17)(q22;q21q26) PML/ADAMTS17/RARA

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3100

Clinics and Pathology

Disease Acute promyelocytic leukemia (FAB type M3)

Genes involved and Proteins

Gene Name
Gene NameRARA
Location 17q21.2

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Cryptic insertion (15;17) in a case of acute promyelocytic leukemia detected by fluorescence in situ hybridization
Gutiérrez NC, García JL, Chillón C, Muntión S, González M, Hernández JM
Haematologica 1999 Jan;84(1):88-90
PMID 10091399
 
Atypical mRNA fusions in PML-RARA positive, RARA-PML negative acute promyelocytic leukemia
Walz C, Grimwade D, Saussele S, Lengfelder E, Haferlach C, Schnittger S, Lafage-Pochitaloff M, Hochhaus A, Cross NC, Reiter A
Genes Chromosomes Cancer 2010 May;49(5):471-9
PMID 20155840
 
A novel PML-ADAMTS17-RARA gene rearrangement in a patient with pregnancy-related acute promyelocytic leukemia
Lim G, Cho EH, Cho SY, Shin SY, Park JC, Yang YJ, Oh SH, Marschalek R, Meyer C, Park TS
Leuk Res 2011 Jul;35(7):e106-10
PMID 21529941
 
Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia
Grimwade D, Gorman P, Duprez E, Howe K, Langabeer S, Oliver F, Walker H, Culligan D, Waters J, Pomfret M, Goldstone A, Burnett A, Freemont P, Sheer D, Solomon E
Blood 1997 Dec 15;90(12):4876-85
 


Translocations implicated (Data extracted from papers in the Atlas)

 ins(15;17)(q22;q21q26) PML/ADAMTS17/RARA

External links

PML/ADAMTS17 () RARA (17q21.2)

Mitelman databaseins(15;17)(q22;q21q26) [Case List]    ins(15;17)(q22;q21q26) [Transloc-MCList] PML/ADAMTS17/RARA [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:20:29 CET 2018


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