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ins(21;20)(q22;q11q11) RUNX1/CBFA2T2

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3160

Clinics and Pathology

Disease Acute myeloid leukemia, NOS

Genes involved and Proteins

Gene NameRUNX1
Location 21q22.12
Gene NameCBFA2T2
Location 20q11.21-q11.22

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia
Guastadisegni MC, Lonoce A, Impera L, Di Terlizzi F, Fugazza G, Aliano S, Grasso R, Cluzeau T, Raynaud S, Rocchi M, Storlazzi CT
Leukemia 2010 Aug;24(8):1516-9
PMID 20520637
 


Translocations implicated (Data extracted from papers in the Atlas)

 ins(21;20)(q22;q11q11) RUNX1/CBFA2T2

External links

RUNX1 (21q22.12) CBFA2T2 (20q11.21-q11.22)

Mitelman databaseins(21;20)(q22;q11q11) [Case List]    ins(21;20)(q22;q11q11) [Transloc-MCList] RUNX1/CBFA2T2 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Fri Feb 23 20:22:48 CET 2018


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