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inv(2)(p21p23) EML4/ALK

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3373
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Chronic lymphocytic leukemia|Diffuse large B-cell lymphoma|Follicular lymphoma|Hodgkin disease, NOS|Nonneoplastic hematologic disorder/lesion|Peripheral T-cell lymphoma, unspecified

Genes involved and Proteins

Gene NameEML4
Location 2p21
Gene NameALK
Location 2p23.2-p23.1

Bibliography

The EML4-ALK transcript but not the fusion protein can be expressed in reactive and neoplastic lymphoid tissues
Sozzi G, Martelli MP, Conte D, Modena P, Pettirossi V, Pileri SA, Falini B
Haematologica 2009 Sep;94(9):1307-11
PMID 19734424
 


Translocations implicated (Data extracted from papers in the Atlas)

 inv(2)(p21p23) EML4/ALK

External links

EML4 (2p21) ALK (2p23.2-p23.1)

Mitelman databaseinv(2)(p21p23) [Case List]    inv(2)(p21p23) [Transloc-MCList] EML4/ALK [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Jul 9 10:12:54 CEST 2018


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