Atlas of Genetics and Cytogenetics in Oncology and Haematology

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inv(2)(p21p23) EML4::ALK

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Atlas_Id 3373
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Chronic lymphocytic leukemia|Diffuse large B-cell lymphoma|Follicular lymphoma|Hodgkin disease, NOS|Nonneoplastic hematologic disorder/lesion|Peripheral T-cell lymphoma, unspecified

Genes involved and Proteins

Gene NameEML4
Location 2p21
Gene NameALK
Location 2p23.2


The EML4-ALK transcript but not the fusion protein can be expressed in reactive and neoplastic lymphoid tissues
Sozzi G, Martelli MP, Conte D, Modena P, Pettirossi V, Pileri SA, Falini B
Haematologica 2009 Sep;94(9):1307-11
PMID 19734424

Translocations implicated (Data extracted from papers in the Atlas)

 inv(2)(p21p23) EML4/ALK

External links

EML4 (2p21) ALK (2p23.2)

Mitelman databaseinv(2)(p21p23)
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Fri Oct 8 16:37:43 CEST 2021

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