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t(1;4)(p34;p16) THRAP3/SH3BP2

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3256

Clinics and Pathology

Disease Acute megakaryoblastic leukemia (FAB type M7)

Genes involved and Proteins

Gene NameTHRAP3
Location 1p34.3
Gene NameSH3BP2
Location 4p16.3

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models
Thiollier C, Lopez CK, Gerby B, Ignacimouttou C, Poglio S, Duffourd Y, Guégan J, Rivera-Munoz P, Bluteau O, Mabialah V, Diop M, Wen Q, Petit A, Bauchet AL, Reinhardt D, Bornhauser B, Gautheret D, Lecluse Y, Landman-Parker J, Radford I, Vainchenker W, Dastugue N, de Botton S, Dessen P, Bourquin JP, Crispino JD, Ballerini P, Bernard OA, Pflumio F, Mercher T
J Exp Med 2012 Oct 22;209(11):2017-31
PMID 23045605
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(1;4)(p34;p16) THRAP3/SH3BP2

External links

THRAP3 (1p34.3) SH3BP2 (4p16.3)

Mitelman databaset(1;4)(p34;p16) [Case List]    t(1;4)(p34;p16) [Transloc-MCList] THRAP3/SH3BP2 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Fri Feb 23 20:22:56 CET 2018


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