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t(1;5)(q22;q33) MEF2D/CSF1R

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 1709

Clinics and Pathology

Disease -

Genes involved and Proteins

Gene NameMEF2D
Location 1q22
Gene NameCSF1R
Location 5q32

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib
Lilljebjörn H, Ågerstam H, Orsmark-Pietras C, Rissler M, Ehrencrona H, Nilsson L, Richter J, Fioretos T
Leukemia 2014 Apr;28(4):977-9
PMID 24186003
 
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey RC, McCastlain K, Reshmi SC, Payne-Turner D, Iacobucci I, Shao Y, Chen IM, Valentine M, Pei D, Mungall KL, Mungall AJ, Ma Y, Moore R, Marra M, Stonerock E, Gastier-Foster JM, Devidas M, Dai Y, Wood B, Borowitz M, Larsen EE, Maloney K, Mattano LA Jr, Angiolillo A, Salzer WL, Burke MJ, Gianni F, Spinelli O, Radich JP, Minden MD, Moorman AV, Patel B, Fielding AK, Rowe JM, Luger SM, Bhatia R, Aldoss I, Forman SJ, Kohlschmidt J, Mrózek K, Marcucci G, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Paietta E, Willman CL, Loh ML, Hunger SP, Mullighan CG
Nat Commun 2016 Nov 8;7:13331
PMID 27824051
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(1;5)(q22;q33) MEF2D/CSF1R

External links

MEF2D (1q22) CSF1R (5q32)

Mitelman databaset(1;5)(q22;q33) [Case List]    t(1;5)(q22;q33) [Transloc-MCList] MEF2D/CSF1R [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:20:39 CET 2018


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