Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(1;14)(p33;q11) TRD::TAL1

(Note : for Links provided by Atlas : click)


Atlas_Id 3297
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameTRD
Location 14q11.2
Gene NameTAL1
Location 1p33


Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias
Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffe M, Berger R, Larsen CJ, Mathieu-Mahul D
Genes Chromosomes Cancer 1990 Jan;1(3):194-208
PMID 1964581
The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein
Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R
EMBO J 1990 Feb;9(2):415-24
PMID 2303035
Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma
Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM
Proc Natl Acad Sci U S A 1989 Jul;86(13):5039-43
PMID 2740341
Characterization of translocation t(1;14)(p32;q11) in a T and in a B acute leukemia
Bernard O, Barin C, Charrin C, Mathieu-Mahul D, Berger R
Leukemia 1993 Oct;7(10):1509-13
PMID 8412312

Translocations implicated (Data extracted from papers in the Atlas)

 t(1;14)(p33;q11) TRD/TAL1

External links

TRD (14q11.2) TAL1 (1p33)

Mitelman databaset(1;14)(p33;q11)
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Fri Oct 8 16:37:58 CEST 2021

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