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t(1;17)(q42;q21) IRF2BP2/RARA

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 3386
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute promyelocytic leukemia (FAB type M3)

Genes involved and Proteins

Gene NameIRF2BP2
Location 1q42.3
Gene NameRARA
Location 17q21.2


Identification of a novel fusion gene, IRF2BP2-RARA, in acute promyelocytic leukemia
Yin CC, Jain N, Mehrotra M, Zhagn J, Protopopov A, Zuo Z, Pemmaraju N, DiNardo C, Hirsch-Ginsberg C, Wang SA, Medeiros LJ, Chin L, Patel KP, Ravandi F, Futreal A, Bueso-Ramos CE
J Natl Compr Canc Netw 2015 Jan;13(1):19-22
PMID 25583766
New variant of acute promyelocytic leukemia with IRF2BP2-RARA fusion
Shimomura Y, Mitsui H, Yamashita Y, Kamae T, Kanai A, Matsui H, Ishibashi T, Tanimura A, Shibayama H, Oritani K, Kuyama J, Kanakura Y
Cancer Sci 2016 Aug;107(8):1165-8
PMID 27193600

Translocations implicated (Data extracted from papers in the Atlas)

 t(1;17)(q42;q21) IRF2BP2/RARA

External links

IRF2BP2 (1q42.3) RARA (17q21.2)

Mitelman databaset(1;17)(q42;q21) [Case List]    t(1;17)(q42;q21) [Transloc-MCList] IRF2BP2/RARA [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Tue Mar 12 13:13:01 CET 2019

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