Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(1;17)(q42;q21) IRF2BP2/RARA

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3386
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute promyelocytic leukemia (FAB type M3)

Genes involved and Proteins

Gene NameIRF2BP2
Gene NameRARA
Location 17q21.2

Bibliography

Identification of a novel fusion gene, IRF2BP2-RARA, in acute promyelocytic leukemia
Yin CC, Jain N, Mehrotra M, Zhagn J, Protopopov A, Zuo Z, Pemmaraju N, DiNardo C, Hirsch-Ginsberg C, Wang SA, Medeiros LJ, Chin L, Patel KP, Ravandi F, Futreal A, Bueso-Ramos CE
J Natl Compr Canc Netw 2015 Jan;13(1):19-22
PMID 25583766
 
New variant of acute promyelocytic leukemia with IRF2BP2-RARA fusion
Shimomura Y, Mitsui H, Yamashita Y, Kamae T, Kanai A, Matsui H, Ishibashi T, Tanimura A, Shibayama H, Oritani K, Kuyama J, Kanakura Y
Cancer Sci 2016 Aug;107(8):1165-8
PMID 27193600
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(1;17)(q42;q21) IRF2BP2/RARA

External links

IRF2BP2 () RARA (17q21.2)

Mitelman databaset(1;17)(q42;q21) [Case List]    t(1;17)(q42;q21) [Transloc-MCList] IRF2BP2/RARA [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jul 9 10:13:15 CEST 2018


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.