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t(1;21)(p32;q22) RUNX1/NDC1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3172
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute myeloid leukemia, NOS

Genes involved and Proteins

Gene NameRUNX1
Location 21q22.12
Gene NameNDC1
Location 1p32.3

Bibliography

Truncated RUNX1 protein generated by a novel t(1;21)(p32;q22) chromosomal translocation impairs the proliferation and differentiation of human hematopoietic progenitors
Rodriguez-Perales S, Torres-Ruiz R, Suela J, Acquadro F, Martin MC, Yebra E, Ramirez JC, Alvarez S, Cigudosa JC
Oncogene 2016 Jan 7;35(1):125-34
PMID 25798834
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(1;21)(p32;q22) RUNX1/NDC1

External links

RUNX1 (21q22.12) NDC1 (1p32.3)

Mitelman databaset(1;21)(p32;q22) [Case List]    t(1;21)(p32;q22) [Transloc-MCList] RUNX1/NDC1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Aug 28 18:19:06 CEST 2018


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