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inv(2)(p23q13)|t(2;2)(p23;q13) RANBP2/ALK

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3387
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute myeloid leukemia, NOS|Acute myelomonocytic leukemia (FAB type M4)|Diffuse large B-cell lymphoma|Juvenile myelomonocytic leukemia|Myelodysplastic syndrome, NOS

Genes involved and Proteins

Gene NameRANBP2
Location 2q13
Gene NameALK
Location 2p23.2-p23.1

Bibliography

ALK fusion genes in children with atypical myeloproliferative leukemia
Röttgers S, Gombert M, Teigler-Schlegel A, Busch K, Gamerdinger U, Slany R, Harbott J, Borkhardt A
Leukemia 2010 Jun;24(6):1197-200
PMID 20428197
 
ALK fusion genes in children with atypical myeloproliferative leukemia
Röttgers S, Gombert M, Teigler-Schlegel A, Busch K, Gamerdinger U, Slany R, Harbott J, Borkhardt A
Leukemia 2010 Jun;24(6):1197-200
PMID 20428197
 
RANBP2-ALK fusion combined with monosomy 7 in acute myelomonocytic leukemia
Lim JH, Jang S, Park CJ, Cho YU, Lee JH, Lee KH, Lee JO, Shin JY, Kim JI, Huh J, Seo EJ
Cancer Genet 2014 Jan-Feb;207(1-2):40-5
PMID 24613277
 
inv(2)(p23q13)/RAN-binding protein 2 (RANBP2)-ALK fusion gene in myeloid leukemia that developed in an elderly woman
Maesako Y, Izumi K, Okamori S, Takeoka K, Kishimori C, Okumura A, Honjo G, Akasaka T, Ohno H
Int J Hematol 2014 Feb;99(2):202-7
PMID 24307515
 
Crizotinib resistance in acute myeloid leukemia with inv(2)(p23q13)/RAN binding protein 2 (RANBP2) anaplastic lymphoma kinase (ALK) fusion and monosomy 7
Takeoka K, Okumura A, Maesako Y, Akasaka T, Ohno H
Cancer Genet 2015 Mar;208(3):85-90
PMID 25766836
 
Identification of RANBP2-ALK fusion in ALK positive diffuse large B-cell lymphoma
Lee SE, Kang SY, Takeuchi K, Ko YH
Hematol Oncol 2014 Dec;32(4):221-4
PMID 24470379
 


Translocations implicated (Data extracted from papers in the Atlas)

 inv(2)(p23q13)|t(2;2)(p23;q13) RANBP2/ALK

External links

RANBP2 (2q13) ALK (2p23.2-p23.1)

Mitelman databaseinv(2)(p23q13)|t(2;2)(p23;q13) [Case List]    inv(2)(p23q13)|t(2;2)(p23;q13) [Transloc-MCList] RANBP2/ALK [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Jul 9 10:13:19 CEST 2018


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