t(2;4)(p23;q21) SEC31A/ALK

Identity

ICD-Topo	C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id	3189
Note	Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease

Diffuse large B-cell lymphoma

Genes involved and Proteins

Gene Name	SEC31A
Location	4q21.22

Gene Name	ALK
Location	2p23.2

Bibliography

ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions

Van Roosbroeck K, Cools J, Dierickx D, Thomas J, Vandenberghe P, Stul M, Delabie J, De Wolf-Peeters C, Marynen P, Wlodarska I

Haematologica 2010 Mar;95(3):509-13

PMID 20207848

Cytogenetically complex SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas

Bedwell C, Rowe D, Moulton D, Jones G, Bown N, Bacon CM

Haematologica 2011 Feb;96(2):343-6

PMID 21109691

Translocations implicated (Data extracted from papers in the Atlas)

	t(2;4)(p23;q21) SEC31A/ALK

External links

SEC31A (4q21.22) ALK (2p23.2)

Mitelman database	t(2;4)(p23;q21) [Case List]    t(2;4)(p23;q21) [Transloc-MCList] SEC31A/ALK [Fusion-MCList]
COSMIC	Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)	[select an item]

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed
All articles	automatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 12 17:01:29 CEST 2019

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