Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(2;4)(p23;q21) SEC31A::ALK

(Note : for Links provided by Atlas : click)


Atlas_Id 3189
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Diffuse large B-cell lymphoma

Genes involved and Proteins

Gene NameSEC31A
Location 4q21.22
Gene NameALK
Location 2p23.2


ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions
Van Roosbroeck K, Cools J, Dierickx D, Thomas J, Vandenberghe P, Stul M, Delabie J, De Wolf-Peeters C, Marynen P, Wlodarska I
Haematologica 2010 Mar;95(3):509-13
PMID 20207848
Cytogenetically complex SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas
Bedwell C, Rowe D, Moulton D, Jones G, Bown N, Bacon CM
Haematologica 2011 Feb;96(2):343-6
PMID 21109691

Translocations implicated (Data extracted from papers in the Atlas)

 t(2;4)(p23;q21) SEC31A/ALK

External links

SEC31A (4q21.22) ALK (2p23.2)

Mitelman databaset(2;4)(p23;q21)
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Fri Oct 8 16:38:03 CEST 2021

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