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t(2;4)(p23;q21) SEC31A/ALK

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3189
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Diffuse large B-cell lymphoma

Genes involved and Proteins

Gene NameSEC31A
Location 4q21.22
Gene NameALK
Location 2p23.2-p23.1

Bibliography

ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions
Van Roosbroeck K, Cools J, Dierickx D, Thomas J, Vandenberghe P, Stul M, Delabie J, De Wolf-Peeters C, Marynen P, Wlodarska I
Haematologica 2010 Mar;95(3):509-13
PMID 20207848
 
Cytogenetically complex SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas
Bedwell C, Rowe D, Moulton D, Jones G, Bown N, Bacon CM
Haematologica 2011 Feb;96(2):343-6
PMID 21109691
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(2;4)(p23;q21) SEC31A/ALK

External links

SEC31A (4q21.22) ALK (2p23.2-p23.1)

Mitelman databaset(2;4)(p23;q21) [Case List]    t(2;4)(p23;q21) [Transloc-MCList] SEC31A/ALK [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
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indexed on : Mon May 14 13:42:02 CEST 2018


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