| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| Atlas_Id | 3189 |
| Note | Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to How to contribute |
| Clinics and Pathology |
| Disease | Diffuse large B-cell lymphoma |
| Genes involved and Proteins |
| Gene Name | SEC31A |
| Location | 4q21.22 |
| Gene Name | ALK |
| Location | 2p23.2 |
| Bibliography |
| ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions |
| Van Roosbroeck K, Cools J, Dierickx D, Thomas J, Vandenberghe P, Stul M, Delabie J, De Wolf-Peeters C, Marynen P, Wlodarska I |
| Haematologica 2010 Mar;95(3):509-13 |
| PMID 20207848 |
| Cytogenetically complex SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas |
| Bedwell C, Rowe D, Moulton D, Jones G, Bown N, Bacon CM |
| Haematologica 2011 Feb;96(2):343-6 |
| PMID 21109691 |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(2;4)(p23;q21) SEC31A/ALK | |
| External links |
| Mitelman database | t(2;4)(p23;q21) |
| COSMIC | Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC) |
| arrayMap (UZH-SIB Zurich) | [select an item] |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:27:16 CET 2020 |
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