Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(2;8)(p11;q24) IGK/PVT1

Written2018-01Jean-Loup Huret, Philippe Dessen

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Atlas_Id 2820

Clinics and Pathology

Disease Burkitt lymphoma/leukemia

Genes involved and Proteins

Gene NameIGK
Location 2p11.2
Gene NamePVT1
Location 8q24.21

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute


Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma
Onciu M, Schlette E, Zhou Y, Raimondi SC, Giles FJ, Kantarjian HM, Medeiros LJ, Ribeiro RC, Pui CH, Sandlund JT
Cancer 2006 Sep 1;107(5):1084-92
PMID 16862570
Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma
Shtivelman E, Henglein B, Groitl P, Lipp M, Bishop JM
Proc Natl Acad Sci U S A 1989 May;86(9):3257-60
PMID 2470097
Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc
Henglein B, Synovzik H, Groitl P, Bornkamm GW, Hartl P, Lipp M
Mol Cell Biol 1989 May;9(5):2105-13
PMID 2747644
Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus
Graham M, Adams JM
EMBO J 1986 Nov;5(11):2845-51
PMID 3024964
A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) Burkitt lymphoma
Taub R, Kelly K, Battey J, Latt S, Lenoir GM, Tantravahi U, Tu Z, Leder P
Cell 1984 Jun;37(2):511-20
PMID 6327071
Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription
Erikson J, Nishikura K, ar-Rushdi A, Finan J, Emanuel B, Lenoir G, Nowell PC, Croce CM
Proc Natl Acad Sci U S A 1983 Dec;80(24):7581-5
PMID 6424112
The 2p breakpoint of a 2;8 translocation in Burkitt lymphoma interrupts the V kappa locus
Emanuel BS, Selden JR, Chaganti RS, Jhanwar S, Nowell PC, Croce CM
Proc Natl Acad Sci U S A 1984 Apr;81(8):2444-6
PMID 6585808

Translocations implicated (Data extracted from papers in the Atlas)

 t(2;8)(p11;q24) IGK/PVT1

External links

IGK (2p11.2) PVT1 (8q24.21)

Mitelman databaset(2;8)(p11;q24) [Case List]    t(2;8)(p11;q24) [Transloc-MCList] IGK/PVT1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Fri Feb 23 20:23:13 CET 2018

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