t(2;8)(p11;q24) IGK/PVT1

2018-01-01   Philippe Dessen , Jean-Loup Huret 

Clinics and Pathology

Disease

Burkitt lymphoma/leukemia

Genes Involved and Proteins

Gene name
IGK
Location
2p11.2
Gene name
PVT1
Location
8q24.21

Bibliography

Pubmed IDLast YearTitleAuthors
24700971989Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma.Shtivelman E et al
27476441989Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.Henglein B et al
30249641986Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus.Graham M et al

Summary

Fusion gene

IGK/PVT1 IGK (2p11.2) PVT1 (8q24.21)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Philippe Dessen ; Jean-Loup Huret

t(2;8)(p11;q24) IGK/PVT1

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2820/t(2;8)(p11;q24)-igk-pvt1