Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(2;8)(p11;q24) IGK/PVT1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2820
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Burkitt lymphoma/leukemia

Genes involved and Proteins

Gene NameIGK
Location 2p11.2
Gene NamePVT1
Location 8q24.21

Bibliography

Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma
Shtivelman E, Henglein B, Groitl P, Lipp M, Bishop JM
Proc Natl Acad Sci U S A 1989 May;86(9):3257-60
PMID 2470097
 
Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc
Henglein B, Synovzik H, Groitl P, Bornkamm GW, Hartl P, Lipp M
Mol Cell Biol 1989 May;9(5):2105-13
PMID 2747644
 
Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus
Graham M, Adams JM
EMBO J 1986 Nov;5(11):2845-51
PMID 3024964
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(2;8)(p11;q24) IGK/PVT1

External links

IGK (2p11.2) PVT1 (8q24.21)

Mitelman databaset(2;8)(p11;q24) [Case List]    t(2;8)(p11;q24) [Transloc-MCList] IGK/PVT1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon May 14 13:42:06 CEST 2018


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.