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t(2;8)(p11;q24) IGK/MYC

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3390
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease B-prolymphocytic leukemia|Burkitt lymphoma/leukemia|Diffuse large B-cell lymphoma|Follicular lymphoma|Mantle cell lymphoma

Genes involved and Proteins

Gene NameIGK
Location 2p11.2
Gene NameMYC
Location 8q24.21

Bibliography

B cell prolymphocytic leukaemia (B-PLL) with complex karyotype and concurrent abnormalities of the p53 and c-MYC gene
Lens D, Coignet LJ, Brito-Babapulle V, Lima CS, Matutes E, Dyer MJ, Catovsky D
Leukemia 1999 Jun;13(6):873-6
PMID 10360375
 
Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain loci
Martín-Subero JI, Harder L, Gesk S, Schlegelberger B, Grote W, Martinez-Climent JA, Dyer MJ, Novo FJ, Calasanz MJ, Siebert R
Int J Cancer 2002 Mar 20;98(3):470-4
PMID 11920602
 
Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain loci
Martín-Subero JI, Harder L, Gesk S, Schlegelberger B, Grote W, Martinez-Climent JA, Dyer MJ, Novo FJ, Calasanz MJ, Siebert R
Int J Cancer 2002 Mar 20;98(3):470-4
PMID 11920602
 
Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain loci
Martín-Subero JI, Harder L, Gesk S, Schlegelberger B, Grote W, Martinez-Climent JA, Dyer MJ, Novo FJ, Calasanz MJ, Siebert R
Int J Cancer 2002 Mar 20;98(3):470-4
PMID 11920602
 
MYC-IG rearrangements are negative predictors of survival in DLBCL patients treated with immunochemotherapy: a GELA/LYSA study
Copie-Bergman C, Cuillière-Dartigues P, Baia M, Briere J, Delarue R, Canioni D, Salles G, Parrens M, Belhadj K, Fabiani B, Recher C, Petrella T, Ketterer N, Peyrade F, Haioun C, Nagel I, Siebert R, Jardin F, Leroy K, Jais JP, Tilly H, Molina TJ, Gaulard P
Blood 2015 Nov 26;126(22):2466-74
PMID 26373676
 
A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) Burkitt lymphoma
Taub R, Kelly K, Battey J, Latt S, Lenoir GM, Tantravahi U, Tu Z, Leder P
Cell 1984 Jun;37(2):511-20
PMID 6327071
 
Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription
Erikson J, Nishikura K, ar-Rushdi A, Finan J, Emanuel B, Lenoir G, Nowell PC, Croce CM
Proc Natl Acad Sci U S A 1983 Dec;80(24):7581-5
PMID 6424112
 
The 2p breakpoint of a 2;8 translocation in Burkitt lymphoma interrupts the V kappa locus
Emanuel BS, Selden JR, Chaganti RS, Jhanwar S, Nowell PC, Croce CM
Proc Natl Acad Sci U S A 1984 Apr;81(8):2444-6
PMID 6585808
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(2;8)(p11;q24) IGK/MYC

External links

IGK (2p11.2) MYC (8q24.21)

Mitelman databaset(2;8)(p11;q24) [Case List]    t(2;8)(p11;q24) [Transloc-MCList] IGK/MYC [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Aug 28 18:19:15 CEST 2018


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