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t(2;10)(p15;p12) XPO1/MLLT10

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3334
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameXPO1
Location 2p15
Gene NameMLLT10
Location 10p12.31

Bibliography

Cryptic XPO1-MLLT10 translocation is associated with HOXA locus deregulation in T-ALL
Bond J, Bergon A, Durand A, Tigaud I, Thomas X, Asnafi V, Spicuglia S, Macintyre E
Blood 2014 Nov 6;124(19):3023-5
PMID 25377562
 

Translocations implicated (Data extracted from papers in the Atlas)

 t(2;10)(p15;p12) XPO1/MLLT10

External links

XPO1 (2p15) MLLT10 (10p12.31)

Mitelman databaset(2;10)(p15;p12) [Case List]    t(2;10)(p15;p12) [Transloc-MCList] XPO1/MLLT10 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
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indexed on : Mon Mar 25 16:50:40 CET 2019

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