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t(2;11)(q31;p15) NUP98/HOXD13

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 1146
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute erythroleukemia (FAB type M6)|Acute myelomonocytic leukemia (FAB type M4)|Chronic myeloid leukemia, t(9;22)

Genes involved and Proteins

Gene NameNUP98
Location 11p15.4
Gene NameHOXD13
Location 2q31.1

Bibliography

Generation of the NUP98-HOXD13 fusion transcript by a rare translocation, t(2;11)(q31;p15), in a case of infant leukaemia
Shimada H, Arai Y, Sekiguchi S, Ishii T, Tanitsu S, Sasaki M
Br J Haematol 2000 Jul;110(1):210-3
PMID 10931000
 
Heterogenous fusion transcripts involving the NUP98 gene and HOXD13 gene activation in a case of acute myeloid leukemia with the t(2;11)(q31;p15) translocation
Arai Y, Kyo T, Miwa H, Arai K, Kamada N, Kita K, Ohki M
Leukemia 2000 Sep;14(9):1621-9
PMID 10995009
 
Analysis of translocations that involve the NUP98 gene in patients with 11p15 chromosomal rearrangements
Kobzev YN, Martinez-Climent J, Lee S, Chen J, Rowley JD
Genes Chromosomes Cancer 2004 Dec;41(4):339-52
PMID 15390187
 
NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia
Raza-Egilmez SZ, Jani-Sait SN, Grossi M, Higgins MJ, Shows TB, Aplan PD
Cancer Res 1998 Oct 1;58(19):4269-73
PMID 9766650
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(2;11)(q31;p15) NUP98/HOXD13

External links

NUP98 (11p15.4) HOXD13 (2q31.1)

Mitelman databaset(2;11)(q31;p15) [Case List]    t(2;11)(q31;p15) [Transloc-MCList] NUP98/HOXD13 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Nov 6 14:05:19 CET 2018


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