Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(2;12)(p11;p13) IGK/CCND2

Written2018-01Jean-Loup Huret, Philippe Dessen

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Atlas_Id 3392
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Mantle cell lymphoma

Genes involved and Proteins

Gene NameIGK
Location 2p11.2
Gene NameCCND2
Location 12p13.32


A chromosomal translocation in cyclin D1-negative/cyclin D2-positive mantle cell lymphoma fuses the CCND2 gene to the IGK locus
Gesk S, Klapper W, Martín-Subero JI, Nagel I, Harder L, Fu K, Bernd HW, Weisenburger DD, Parwaresch R, Siebert R
Blood 2006 Aug 1;108(3):1109-10
PMID 16861358
Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas
Wlodarska I, Dierickx D, Vanhentenrijk V, Van Roosbroeck K, Pospísilová H, Minnei F, Verhoef G, Thomas J, Vandenberghe P, De Wolf-Peeters C
Blood 2008 Jun 15;111(12):5683-90
PMID 18391076

Translocations implicated (Data extracted from papers in the Atlas)

 t(2;12)(p11;p13) IGK/CCND2

External links

IGK (2p11.2) CCND2 (12p13.32)

Mitelman databaset(2;12)(p11;p13) [Case List]    t(2;12)(p11;p13) [Transloc-MCList] IGK/CCND2 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Mon Aug 12 17:01:34 CEST 2019

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