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t(2;14)(p16;q32) IGH/BCL11A

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3394
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Chronic lymphocytic leukemia

Genes involved and Proteins

Gene NameIGH
Location 14q32.33
Gene NameBCL11A
Location 2p16.1

Bibliography

The BCL11 gene family: involvement of BCL11A in lymphoid malignancies
Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, Liu H, Price HP, Gesk S, Steinemann D, Schlegelberger B, Oscier DG, Siebert R, Tucker PW, Dyer MJ
Blood 2001 Dec 1;98(12):3413-20
PMID 11719382
 
Lack of somatic hypermutation of IG V(H) genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene
Küppers R, Sonoki T, Satterwhite E, Gesk S, Harder L, Oscier DG, Tucker PW, Dyer MJ, Siebert R
Leukemia 2002 May;16(5):937-9
PMID 11986957
 
Chronic lymphocytic leukemia With t(2;14)(p16;q32) involves the BCL11A and IgH genes and is associated with atypical morphologic features and unmutated IgVH genes
Yin CC, Lin KI, Ketterling RP, Knudson RA, Medeiros LJ, Barron LL, Huh YO, Luthra R, Keating MJ, Abruzzo LV
Am J Clin Pathol 2009 May;131(5):663-70
PMID 19369625
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(2;14)(p16;q32) IGH/BCL11A

External links

IGH (14q32.33) BCL11A (2p16.1)

Mitelman databaset(2;14)(p16;q32) [Case List]    t(2;14)(p16;q32) [Transloc-MCList] IGH/BCL11A [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Jul 9 10:13:29 CEST 2018


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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.