Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(2;22)(p13;q11) REL/IGL

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 1354

Clinics and Pathology

Disease -

Genes involved and Proteins

Gene NameREL
Location 1q32.1
Gene NameIGL
Location 19q13.41

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute


Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain loci
Martín-Subero JI, Harder L, Gesk S, Schlegelberger B, Grote W, Martinez-Climent JA, Dyer MJ, Novo FJ, Calasanz MJ, Siebert R
Int J Cancer 2002 Mar 20;98(3):470-4
PMID 11920602
Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2-positive germinal center B-cell lymphomas
Martín-Subero JI, Odero MD, Hernandez R, Cigudosa JC, Agirre X, Saez B, Sanz-García E, Ardanaz MT, Novo FJ, Gascoyne RD, Calasanz MJ, Siebert R
Genes Chromosomes Cancer 2005 Aug;43(4):414-23
PMID 15852472
Chromosomal breakpoints affecting immunoglobulin loci are recurrent in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma
Martín-Subero JI, Klapper W, Sotnikova A, Callet-Bauchu E, Harder L, Bastard C, Schmitz R, Grohmann S, Höppner J, Riemke J, Barth TF, Berger F, Bernd HW, Claviez A, Gesk S, Frank GA, Kaplanskaya IB, Möller P, Parwaresch RM, Rüdiger T, Stein H, Küppers R, Hansmann ML, Siebert R; Deutsche Krebshilfe Network Project Molecular Mechanisms in Malignant Lymphomas
Cancer Res 2006 Nov 1;66(21):10332-8
PMID 17079453

Translocations implicated (Data extracted from papers in the Atlas)

 t(2;22)(p13;q11) REL/IGL

External links

REL (1q32.1) IGL (19q13.41)

Mitelman databaset(2;22)(p13;q11) [Case List]    t(2;22)(p13;q11) [Transloc-MCList] REL/IGL [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Jan 10 17:21:01 CET 2018

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