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t(3;3)(q27;q27) EIF4A2/BCL6

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3400
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Diffuse large B-cell lymphoma|Follicular lymphoma

Genes involved and Proteins

Gene NameEIF4A2
Location 3q27.3
Gene NameBCL6
Location 3q27.3

Bibliography

Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples
Yoshida S, Kaneita Y, Aoki Y, Seto M, Mori S, Moriyama M
Oncogene 1999 Dec 23;18(56):7994-9
PMID 10637510
 
Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing
Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA
Blood 2013 Aug 15;122(7):1256-65
PMID 23699601
 
BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma
Akasaka T, Lossos IS, Levy R
Blood 2003 Aug 15;102(4):1443-8
PMID 12738680
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(3;3)(q27;q27) EIF4A2/BCL6

External links

EIF4A2 (3q27.3) BCL6 (3q27.3)

Mitelman databaset(3;3)(q27;q27) [Case List]    t(3;3)(q27;q27) [Transloc-MCList] EIF4A2/BCL6 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Jul 9 10:13:36 CEST 2018


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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.