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t(3;4)(q27;p14) RHOH/BCL6

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3402
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Follicular lymphoma|Mature B-cell neoplasm, NOS

Genes involved and Proteins

Gene NameRHOH
Location 4p14
Gene NameBCL6
Location 3q27.3

Bibliography

Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma
Preudhomme C, Roumier C, Hildebrand MP, Dallery-Prudhomme E, Lantoine D, Laï JL, Daudignon A, Adenis C, Bauters F, Fenaux P, Kerckaert JP, Galiègue-Zouitina S
Oncogene 2000 Apr 13;19(16):2023-32
PMID 10803463
 
Heterologous promoters fused to BCL6 by chromosomal translocations affecting band 3q27 cause its deregulated expression during B-cell differentiation
Chen W, Iida S, Louie DC, Dalla-Favera R, Chaganti RS
Blood 1998 Jan 15;91(2):603-7
PMID 9427715
 
TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation
Dallery E, Galiègue-Zouitina S, Collyn-d'Hooghe M, Quief S, Denis C, Hildebrand MP, Lantoine D, Deweindt C, Tilly H, Bastard C, et al
Oncogene 1995 Jun 1;10(11):2171-8
PMID 7784061
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(3;4)(q27;p14) RHOH/BCL6

External links

RHOH (4p14) BCL6 (3q27.3)

Mitelman databaset(3;4)(q27;p14) [Case List]    t(3;4)(q27;p14) [Transloc-MCList] RHOH/BCL6 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Jul 9 10:13:36 CEST 2018


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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.