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t(3;5)(q25;q35) NPM1/MLF1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3404
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute erythroleukemia (FAB type M6)|Acute myeloblastic leukemia with maturation (FAB type M2)|Acute myeloid leukemia, NOS|Acute myelomonocytic leukemia (FAB type M4)|Chronic myeloproliferative disorder, NOS|Refractory anemia with excess blasts-2

Genes involved and Proteins

Gene NameNPM1
Location 5q35.1
Gene NameMLF1
Location 3q25.32

Bibliography

Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia
Arber DA, Chang KL, Lyda MH, Bedell V, Spielberger R, Slovak ML
Hum Pathol 2003 Aug;34(8):809-13
PMID 14506644
 
Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia
Arber DA, Chang KL, Lyda MH, Bedell V, Spielberger R, Slovak ML
Hum Pathol 2003 Aug;34(8):809-13
PMID 14506644
 
Loss of the NPM1 gene in myeloid disorders with chromosome 5 rearrangements
Berger R, Busson M, Baranger L, Hélias C, Lessard M, Dastugue N, Speleman F
Leukemia 2006 Feb;20(2):319-21
PMID 16341035
 
Loss of the NPM1 gene in myeloid disorders with chromosome 5 rearrangements
Berger R, Busson M, Baranger L, Hélias C, Lessard M, Dastugue N, Speleman F
Leukemia 2006 Feb;20(2):319-21
PMID 16341035
 
The t(3;5)(q25
Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW
1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1 Oncogene
PMID 8570204
 
Early acute myeloblastic leukemia treatment for childhood myelodysplastic syndrome with t(3;5) (NPM/MLF1)
Sevilla J, Fernández-Plaza S, Lassaletta A, González-Vicent M, Contra T, Madero L
J Pediatr Hematol Oncol 2007 Dec;29(12):839-40
PMID 18090933
 
Screening for diverse PDGFRA or PDGFRB fusion genes is facilitated by generic quantitative reverse transcriptase polymerase chain reaction analysis
Erben P, Gosenca D, Müller MC, Reinhard J, Score J, Del Valle F, Walz C, Mix J, Metzgeroth G, Ernst T, Haferlach C, Cross NC, Hochhaus A, Reiter A
Haematologica 2010 May;95(5):738-44
PMID 20107158
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(3;5)(q25;q35) NPM1/MLF1

External links

NPM1 (5q35.1) MLF1 (3q25.32)

Mitelman databaset(3;5)(q25;q35) [Case List]    t(3;5)(q25;q35) [Transloc-MCList] NPM1/MLF1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Nov 6 14:05:33 CET 2018


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jlhuret@AtlasGeneticsOncology.org.