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t(3;6)(q27;p21) BCL6/PIM1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2548

Clinics and Pathology

Disease Diffuse large B-cell lymphoma

Genes involved and Proteins

Gene NameBCL6
Location 3q27.3
Gene NamePIM1
Location 6p21.2

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples
Yoshida S, Kaneita Y, Aoki Y, Seto M, Mori S, Moriyama M
Oncogene 1999 Dec 23;18(56):7994-9
PMID 10637510
 
Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing
Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA
Blood 2013 Aug 15;122(7):1256-65
PMID 23699601
 
A new non-random chromosomal translocation t(3;6)(q27;p21
Miura I, Ohshima A, Takahashi N, Hashimoto K, Nimura T, Utsumi S, Saito M, Miki T, Hirosawa S, Miura AB
3) associated with BCL6 rearrangement in two patients with non-Hodgkin's lymphoma Int J Hematol
PMID 8923787
 
Rearrangements of the BCL6 gene and chromosome aberrations affecting 3q27 in 54 patients with non-Hodgkin's lymphoma
Ohshima A, Miura I, Hashimoto K, Takahashi N, Utsumi S, Nimura T, Saito M, Miki T, Hirosawa S, Miura AB
Leuk Lymphoma 1997 Oct;27(3-4):329-34
PMID 9402330
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(3;6)(q27;p21) BCL6/PIM1

External links

BCL6 (3q27.3) PIM1 (6p21.2)

Mitelman databaset(3;6)(q27;p21) [Case List]    t(3;6)(q27;p21) [Transloc-MCList] BCL6/PIM1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:21:05 CET 2018


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