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t(3;7)(q21;p15) GATA2/HOXA10

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2742

Clinics and Pathology

Disease Acute megakaryoblastic leukemia (FAB type M7)

Genes involved and Proteins

Gene NameGATA2
Location 3q21.3
Gene NameHOXA10
Location 7p15.2

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes
de Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, Liang DC, Halene S, Krause DS, Zhang J, Downing JR, Locatelli F, Reinhardt D, van den Heuvel-Eibrink MM, Zwaan CM, Fornerod M, Gruber TA
Nat Genet 2017 Mar;49(3):451-456
PMID 28112737
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(3;7)(q21;p15) GATA2/HOXA10

External links

GATA2 (3q21.3) HOXA10 (7p15.2)

Mitelman databaset(3;7)(q21;p15) [Case List]    t(3;7)(q21;p15) [Transloc-MCList] GATA2/HOXA10 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:21:06 CET 2018


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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.