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t(3;11)(p24;p15) NUP98/TOP2B

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3042

Clinics and Pathology

Disease Acute monoblastic leukemia without differentiation (FAB type M5a)

Genes involved and Proteins

Gene NameNUP98
Location 11p15.4
Gene NameTOP2B
Location 3p24.2

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

NUP98 is fused to topoisomerase (DNA) IIbeta 180 kDa (TOP2B) in a patient with acute myeloid leukemia with a new t(3;11)(p24;p15)
Nebral K, Schmidt HH, Haas OA, Strehl S
Clin Cancer Res 2005 Sep 15;11(18):6489-94
PMID 16166424
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(3;11)(p24;p15) NUP98/TOP2B

External links

NUP98 (11p15.4) TOP2B (3p24.2)

Mitelman databaset(3;11)(p24;p15) [Case List]    t(3;11)(p24;p15) [Transloc-MCList] NUP98/TOP2B [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
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indexed on : Wed Jan 10 17:21:09 CET 2018


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jlhuret@AtlasGeneticsOncology.org.