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t(3;14)(q27;q32):t(3;8;14)(q27;q24;q32) IGH/BCL6

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2787

Clinics and Pathology

Disease Burkitt lymphoma/leukemia:Diffuse large B-cell lymphoma:Follicular lymphoma:Hodgkin disease, lymphocyte predominance:Hodgkin disease, nodular sclerosis:Mature B-cell neoplasm, NOS:Mediastinal large B-cell lymphoma

Genes involved and Proteins

Gene NameIGH
Location 14q32.33
Gene NameBCL6
Location 3q27.3

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Interphase detection of immunoglobulin heavy chain gene translocations with specific oncogene loci in 173 patients with B-cell lymphoma
Tamura A, Miura I, Iida S, Yokota S, Horiike S, Nishida K, Fujii H, Nakamura S, Seto M, Ueda R, Taniwaki M
Cancer Genet Cytogenet 2001 Aug;129(1):1-9
PMID 11520558
 
Alternative translocation breakpoint cluster region 5' to BCL-6 in B-cell non-Hodgkin's lymphoma
Butler MP, Iida S, Capello D, Rossi D, Rao PH, Nallasivam P, Louie DC, Chaganti S, Au T, Gascoyne RD, Gaidano G, Chaganti RS, Dalla-Favera R
Cancer Res 2002 Jul 15;62(14):4089-94
PMID 12124346
 
Unique three-way translocation, t(3;14;18)(q27;q32;q21), in follicular lymphoma
Okano A, Nakano S, Namura K, Yamada N, Uchida R, Fuchida S, Okamoto M, Ochiai N, Shimazaki C
Cancer Genet Cytogenet 2005 Jun;159(2):174-6
 
Translocation of BCL2 and BCL6 to the same immunoglobulin heavy chain locus in a case of follicular lymphoma
Rack K, Delannoy A, Ravoet C, Vannuffel P, Hamels J, Gillerot Y
Leuk Lymphoma 2005 Oct;46(10):1513-6
PMID 16194898
 
Fluorescence in situ hybridization identifies new chromosomal changes involving 3q27 in non-Hodgkin's lymphomas with BCL6/LAZ3 rearrangement
Wlodarska I, Mecucci C, Stul M, Michaux L, Pittaluga S, Hernandez JM, Cassiman JJ, De Wolf-Peeters C, Van den Berghe H
Genes Chromosomes Cancer 1995 Sep;14(1):1-7
PMID 8527378
 
Involvement of BCL6 in chromosomal aberrations affecting band 3q27 in B-cell non-Hodgkin lymphoma
Chaganti SR, Chen W, Parsa N, Offit K, Louie DC, Dalla-Favera R, Chaganti RS
Genes Chromosomes Cancer 1998 Dec;23(4):323-7
PMID 9824205
 
Non-immunoglobulin/BCL6 gene fusion in diffuse large B-cell lymphoma: prognostic implications
Ueda C, Akasaka T, Ohno H
Leuk Lymphoma 2002 Jul;43(7):1375-81
PMID 12389616
 
Molecular characterization of BCL6 breakpoints in primary diffuse large B-cell lymphomas of the central nervous system identifies GAPD as novel translocation partner
Montesinos-Rongen M, Akasaka T, Zühlke-Jenisch R, Schaller C, Van Roost D, Wiestler OD, Siebert R, Deckert M
Brain Pathol 2003 Oct;13(4):534-8
PMID 14655758
 
High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma
Chen YW, Hu XT, Liang AC, Au WY, So CC, Wong ML, Shen L, Tao Q, Chu KM, Kwong YL, Liang RH, Srivastava G
Blood 2006 Oct 1;108(7):2373-83
PMID 16772602
 
Heterogeneity in B-cell neoplasms associated with rearrangement of the LAZ3 gene on chromosome band 3q27
Ohno H, Kerckaert JP, Bastard C, Fukuhara S
Jpn J Cancer Res 1994 Jun;85(6):592-600
PMID 8063612
 
Non-Hodgkin's lymphomas with chromosomal translocations involving 3q27 band and immunoglobulin gene loci: report of two cases
Ohno H, Akasaka T, Ohmura K, Nakamura T, Gohma I, Masuya M, Amano H, Imanaka T, Ohno Y
Cancer Genet Cytogenet 1994 Jan;72(1):33-8
PMID 8111736
 
Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R
Science 1993 Oct 29;262(5134):747-50
PMID 8235596
 
Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma
Ye BH, Chaganti S, Chang CC, Niu H, Corradini P, Chaganti RS, Dalla-Favera R
EMBO J 1995 Dec 15;14(24):6209-17
PMID 8557040
 
Interphase detection of BCL6/IgH fusion gene in non-Hodgkin lymphoma by fluorescence in situ hybridization
Ueda Y, Nishida K, Miki T, Horiike S, Kaneko H, Yokota S, Misawa S, Abe T, Kashima K, Taniwaki M
Cancer Genet Cytogenet 1997 Dec;99(2):102-7
PMID 9398863
 
Heterologous promoters fused to BCL6 by chromosomal translocations affecting band 3q27 cause its deregulated expression during B-cell differentiation
Chen W, Iida S, Louie DC, Dalla-Favera R, Chaganti RS
Blood 1998 Jan 15;91(2):603-7
PMID 9427715
 
Molecular cytogenetic analyses of immunoglobulin loci in nodular lymphocyte predominant Hodgkin's lymphoma reveal a recurrent IGH-BCL6 juxtaposition
Renné C, Martín-Subero JI, Hansmann ML, Siebert R
J Mol Diagn 2005 Aug;7(3):352-6
PMID 16049307
 
Chromosomal breakpoints affecting immunoglobulin loci are recurrent in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma
Martín-Subero JI, Klapper W, Sotnikova A, Callet-Bauchu E, Harder L, Bastard C, Schmitz R, Grohmann S, Höppner J, Riemke J, Barth TF, Berger F, Bernd HW, Claviez A, Gesk S, Frank GA, Kaplanskaya IB, Möller P, Parwaresch RM, Rüdiger T, Stein H, Küppers R, Hansmann ML, Siebert R; Deutsche Krebshilfe Network Project Molecular Mechanisms in Malignant Lymphomas
Cancer Res 2006 Nov 1;66(21):10332-8
PMID 17079453
 
IGH@/BCL6 rearrangement on the der(3)t(3;14)(q27;q32) in primary mediastinal large B-cell lymphoma
Yamamoto K, Okamura A, Inui Y, Yakushijin K, Kawakami F, Itoh T, Matsuoka H, Minami H
Leuk Res 2012 Dec;36(12):e218-21
PMID 22867898
 
Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias
Miki T, Kawamata N, Arai A, Ohashi K, Nakamura Y, Kato A, Hirosawa S, Aoki N
Blood 1994 Jan 1;83(1):217-22
PMID 8274736
 
Two Burkitt-type lymphoma/leukemia-derived cell lines presenting 3q27 translocations and immunoglobulin/BCL6 chimeric transcripts
Nakamura Y, Miki T, Kawamata N, Ohashi K, Hirosawa S, Kobayashi H, Maseki N, Kaneko Y, Saito K, Enokihara H, Furusawa S
Leukemia 1997 Nov;11(11):1993-4
PMID 9369442
 
Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma
Ye BH, Rao PH, Chaganti RS, Dalla-Favera R
Cancer Res 1993 Jun 15;53(12):2732-5
PMID 8504412
 
Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas
Baron BW, Nucifora G, McCabe N, Espinosa R 3rd, Le Beau MM, McKeithan TW
Proc Natl Acad Sci U S A 1993 Jun 1;90(11):5262-6
PMID 8506375
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(3;14)(q27;q32):t(3;8;14)(q27;q24;q32) IGH/BCL6

External links

IGH (14q32.33) BCL6 (3q27.3)

Mitelman databaset(3;14)(q27;q32):t(3;8;14)(q27;q24;q32) [Case List]    t(3;14)(q27;q32):t(3;8;14)(q27;q24;q32) [Transloc-MCList] IGH/BCL6 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:21:10 CET 2018


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