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t(3;14)(q27;q32) IGH/BCL6

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 3408
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Burkitt lymphoma/leukemia|Diffuse large B-cell lymphoma|Follicular lymphoma|Hodgkin disease, lymphocyte predominance|Hodgkin disease, nodular sclerosis|Mature B-cell neoplasm, NOS|Mediastinal large B-cell lymphoma

Genes involved and Proteins

Gene NameIGH
Location 14q32.33
Gene NameBCL6
Location 3q27.3


Interphase detection of immunoglobulin heavy chain gene translocations with specific oncogene loci in 173 patients with B-cell lymphoma
Tamura A, Miura I, Iida S, Yokota S, Horiike S, Nishida K, Fujii H, Nakamura S, Seto M, Ueda R, Taniwaki M
Cancer Genet Cytogenet 2001 Aug;129(1):1-9
PMID 11520558
Alternative translocation breakpoint cluster region 5' to BCL-6 in B-cell non-Hodgkin's lymphoma
Butler MP, Iida S, Capello D, Rossi D, Rao PH, Nallasivam P, Louie DC, Chaganti S, Au T, Gascoyne RD, Gaidano G, Chaganti RS, Dalla-Favera R
Cancer Res 2002 Jul 15;62(14):4089-94
PMID 12124346
Translocation of BCL2 and BCL6 to the same immunoglobulin heavy chain locus in a case of follicular lymphoma
Rack K, Delannoy A, Ravoet C, Vannuffel P, Hamels J, Gillerot Y
Leuk Lymphoma 2005 Oct;46(10):1513-6
PMID 16194898
Molecular cytogenetic analyses of immunoglobulin loci in nodular lymphocyte predominant Hodgkin's lymphoma reveal a recurrent IGH-BCL6 juxtaposition
Renné C, Martín-Subero JI, Hansmann ML, Siebert R
J Mol Diagn 2005 Aug;7(3):352-6
PMID 16049307
Chromosomal breakpoints affecting immunoglobulin loci are recurrent in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma
Martín-Subero JI, Klapper W, Sotnikova A, Callet-Bauchu E, Harder L, Bastard C, Schmitz R, Grohmann S, Höppner J, Riemke J, Barth TF, Berger F, Bernd HW, Claviez A, Gesk S, Frank GA, Kaplanskaya IB, Möller P, Parwaresch RM, Rüdiger T, Stein H, Küppers R, Hansmann ML, Siebert R; Deutsche Krebshilfe Network Project Molecular Mechanisms in Malignant Lymphomas
Cancer Res 2006 Nov 1;66(21):10332-8
PMID 17079453
IGH@/BCL6 rearrangement on the der(3)t(3;14)(q27;q32) in primary mediastinal large B-cell lymphoma
Yamamoto K, Okamura A, Inui Y, Yakushijin K, Kawakami F, Itoh T, Matsuoka H, Minami H
Leuk Res 2012 Dec;36(12):e218-21
PMID 22867898
Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias
Miki T, Kawamata N, Arai A, Ohashi K, Nakamura Y, Kato A, Hirosawa S, Aoki N
Blood 1994 Jan 1;83(1):217-22
PMID 8274736
Two Burkitt-type lymphoma/leukemia-derived cell lines presenting 3q27 translocations and immunoglobulin/BCL6 chimeric transcripts
Nakamura Y, Miki T, Kawamata N, Ohashi K, Hirosawa S, Kobayashi H, Maseki N, Kaneko Y, Saito K, Enokihara H, Furusawa S
Leukemia 1997 Nov;11(11):1993-4
PMID 9369442
Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma
Ye BH, Rao PH, Chaganti RS, Dalla-Favera R
Cancer Res 1993 Jun 15;53(12):2732-5
PMID 8504412
Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas
Baron BW, Nucifora G, McCabe N, Espinosa R 3rd, Le Beau MM, McKeithan TW
Proc Natl Acad Sci U S A 1993 Jun 1;90(11):5262-6
PMID 8506375
Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma
Ye BH, Chaganti S, Chang CC, Niu H, Corradini P, Chaganti RS, Dalla-Favera R
EMBO J 1995 Dec 15;14(24):6209-17
PMID 8557040
Interphase detection of BCL6/IgH fusion gene in non-Hodgkin lymphoma by fluorescence in situ hybridization
Ueda Y, Nishida K, Miki T, Horiike S, Kaneko H, Yokota S, Misawa S, Abe T, Kashima K, Taniwaki M
Cancer Genet Cytogenet 1997 Dec;99(2):102-7
PMID 9398863

Translocations implicated (Data extracted from papers in the Atlas)

 t(3;14)(q27;q32) IGH/BCL6

External links

IGH (14q32.33) BCL6 (3q27.3)

Mitelman databaset(3;14)(q27;q32) [Case List]    t(3;14)(q27;q32) [Transloc-MCList] IGH/BCL6 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Mar 11 20:43:42 CET 2020

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