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t(3;21)(q26;q22) RUNX1/RPL22P1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3177

Clinics and Pathology

Disease Acute myeloblastic leukemia with maturation (FAB type M2):Acute myeloid leukemia, NOS:Chronic myeloid leukemia, t(9;22):Myelodysplastic syndrome, NOS

Genes involved and Proteins

Gene NameRUNX1
Location 21q22.12
Gene NameRPL22P1
Location 3q26.2

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop
Slovak ML, Bedell V, Popplewell L, Arber DA, Schoch C, Slater R
Genes Chromosomes Cancer 2002 Apr;33(4):379-94
PMID 11921272
 
t(3;21)(q26;q22) in myeloid leukemia: an aggressive syndrome of blast transformation associated with hydroxyurea or antimetabolite therapy
Yin CC, Cortes J, Barkoh B, Hayes K, Kantarjian H, Jones D
Cancer 2006 Apr 15;106(8):1730-8
PMID 16532439
 
Myelodysplastic syndrome/acute myeloid leukemia with t(3;21)(q26
Li S, Yin CC, Medeiros LJ, Bueso-Ramos C, Lu G, Lin P
2;q22) is commonly a therapy-related disease associated with poor outcome Am J Clin Pathol
PMID 22706870
 
The landscape and therapeutic relevance of cancer-associated transcript fusions
Yoshihara K, Wang Q, Torres-Garcia W, Zheng S, Vegesna R, Kim H, Verhaak RG
Oncogene 2015 Sep 10;34(37):4845-54
PMID 25500544
 
Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations
Nucifora G, Begy CR, Kobayashi H, Roulston D, Claxton D, Pedersen-Bjergaard J, Parganas E, Ihle JN, Rowley JD
Proc Natl Acad Sci U S A 1994 Apr 26;91(9):4004-8
PMID 8171026
 
Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study
Secker-Walker LM, Mehta A, Bain B
Br J Haematol 1995 Oct;91(2):490-501
PMID 8547101
 
21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop
Slovak ML, Bedell V, Popplewell L, Arber DA, Schoch C, Slater R
Genes Chromosomes Cancer 2002 Apr;33(4):379-94
PMID 11921272
 
Myelodysplastic syndrome/acute myeloid leukemia with t(3;21)(q26
Li S, Yin CC, Medeiros LJ, Bueso-Ramos C, Lu G, Lin P
2;q22) is commonly a therapy-related disease associated with poor outcome Am J Clin Pathol
PMID 22706870
 
Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations
Nucifora G, Begy CR, Kobayashi H, Roulston D, Claxton D, Pedersen-Bjergaard J, Parganas E, Ihle JN, Rowley JD
Proc Natl Acad Sci U S A 1994 Apr 26;91(9):4004-8
PMID 8171026
 
The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1
Nucifora G, Begy CR, Erickson P, Drabkin HA, Rowley JD
Proc Natl Acad Sci U S A 1993 Aug 15;90(16):7784-8
PMID 8395054
 
Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study
Secker-Walker LM, Mehta A, Bain B
Br J Haematol 1995 Oct;91(2):490-501
PMID 8547101
 
t(3;21)(q26;q22) in myeloid leukemia: an aggressive syndrome of blast transformation associated with hydroxyurea or antimetabolite therapy
Yin CC, Cortes J, Barkoh B, Hayes K, Kantarjian H, Jones D
Cancer 2006 Apr 15;106(8):1730-8
PMID 16532439
 
Clinical and prognostic significance of 3q26
Wang W, Cortes JE, Lin P, Beaty MW, Ai D, Amin HM, McDonnell TJ, Ok CY, Kantarjian HM, Medeiros LJ, Hu S
2 and other chromosome 3 abnormalities in CML in the era of tyrosine kinase inhibitors Blood
PMID 26243778
 
Association of a chromosomal 3;21 translocation with the blast phase of chronic myelogenous leukemia
Rubin CM, Larson RA, Bitter MA, Carrino JJ, Le Beau MM, Diaz MO, Rowley JD
Blood 1987 Nov;70(5):1338-42
PMID 3478099
 
AML1 fusion transcripts in t(3;21) positive leukemia: evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts
Sacchi N, Nisson PE, Watkins PC, Faustinella F, Wijsman J, Hagemeijer A
Genes Chromosomes Cancer 1994 Dec;11(4):226-36
PMID 7533526
 
Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations
Nucifora G, Begy CR, Kobayashi H, Roulston D, Claxton D, Pedersen-Bjergaard J, Parganas E, Ihle JN, Rowley JD
Proc Natl Acad Sci U S A 1994 Apr 26;91(9):4004-8
PMID 8171026
 
Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia
Mitani K, Ogawa S, Tanaka T, Miyoshi H, Kurokawa M, Mano H, Yazaki Y, Ohki M, Hirai H
EMBO J 1994 Feb 1;13(3):504-10
PMID 8313895
 
Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study
Secker-Walker LM, Mehta A, Bain B
Br J Haematol 1995 Oct;91(2):490-501
PMID 8547101
 
Abnormalities of the long arm of chromosome 21 in 107 patients with hematopoietic disorders: a collaborative retrospective study of the Groupe Français de Cytogénétique Hématologique
Jeandidier E, Dastugue N, Mugneret F, Lafage-Pochitaloff M, Mozziconacci MJ, Herens C, Michaux L, Verellen-Dumoulin C, Talmant P, Cornillet-Lefebvre P, Luquet I, Charrin C, Barin C, Collonge-Rame MA, Pérot C, Van den Akker J, Grégoire MJ, Jonveaux P, Baranger L, Eclache-Saudreau V, Pagès MP, Cabrol C, Terré C, Berger R; Groupe Français de Cytogénétique Hématologique (GFCH)
Cancer Genet Cytogenet 2006 Apr 1;166(1):1-11
PMID 16616106
 
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
Cancer Genome Atlas Research Network, Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson A, Hoadley K, Triche TJ Jr, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, Klco JM, Koboldt DC, Kanchi KL, Kulkarni S, Lamprecht TL, Larson DE, Lin L, Lu C, McLellan MD, McMichael JF, Payton J, Schmidt H, Spencer DH, Tomasson MH, Wallis JW, Wartman LD, Watson MA, Welch J, Wendl MC, Ally A, Balasundaram M, Birol I, Butterfield Y, Chiu R, Chu A, Chuah E, Chun HJ, Corbett R, Dhalla N, Guin R, He A, Hirst C, Hirst M, Holt RA, Jones S, Karsan A, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall K, Parker J, Pleasance E, Plettner P, Schein J, Stoll D, Swanson L, Tam A, Thiessen N, Varhol R, Wye N, Zhao Y, Gabriel S, Getz G, Sougnez C, Zou L, Leiserson MD, Vandin F, Wu HT, Applebaum F, Baylin SB, Akbani R, Broom BM, Chen K, Motter TC, Nguyen K, Weinstein JN, Zhang N, Ferguson ML, Adams C, Black A, Bowen J, Gastier-Foster J, Grossman T, Lichtenberg T, Wise L, Davidsen T, Demchok JA, Shaw KR, Sheth M, Sofia HJ, Yang L, Downing JR, Eley G
N Engl J Med 2013 May 30;368(22):2059-74
PMID 23634996
 
Translocation (3;21)(q26;q22) in de novo acute myelogenous leukemia
Motomura S, Fujisawa S, Tsunooka S, Fujimaki K, Harano H, Mohri H, Okubo T, Fujita H, Maruta A, Kodama F
Leukemia 1997 Jan;11(1):172-3
PMID 9001437
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(3;21)(q26;q22) RUNX1/RPL22P1

External links

RUNX1 (21q22.12) RPL22P1 (3q26.2)

Mitelman databaset(3;21)(q26;q22) [Case List]    t(3;21)(q26;q22) [Transloc-MCList] RUNX1/RPL22P1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:21:12 CET 2018


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jlhuret@AtlasGeneticsOncology.org.