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t(4;12)(q12;p13) ETV6/PDGFRA

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2709

Clinics and Pathology

Disease Chronic eosinophilic leukemia/hypereosinophilic syndrome

Genes involved and Proteins

Gene NameETV6
Location 12p13.2
Gene NamePDGFRA
Location 4q12

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Two novel imatinib-responsive PDGFRA fusion genes in chronic eosinophilic leukaemia
Curtis CE, Grand FH, Musto P, Clark A, Murphy J, Perla G, Minervini MM, Stewart J, Reiter A, Cross NC
Br J Haematol 2007 Jul;138(1):77-81
PMID 17555450
 
Screening for diverse PDGFRA or PDGFRB fusion genes is facilitated by generic quantitative reverse transcriptase polymerase chain reaction analysis
Erben P, Gosenca D, Müller MC, Reinhard J, Score J, Del Valle F, Walz C, Mix J, Metzgeroth G, Ernst T, Haferlach C, Cross NC, Hochhaus A, Reiter A
Haematologica 2010 May;95(5):738-44
PMID 20107158
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(4;12)(q12;p13) ETV6/PDGFRA

External links

ETV6 (12p13.2) PDGFRA (4q12)

Mitelman databaset(4;12)(q12;p13) [Case List]    t(4;12)(q12;p13) [Transloc-MCList] ETV6/PDGFRA [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:21:17 CET 2018


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