t(4;14)(q35;q32) IGH/DUX4

2018-01-01   Philippe Dessen , Jean-Loup Huret 

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes Involved and Proteins

Gene name
IGH
Location
14q32.33
Gene name
DUX4
Location
4q35.2

Highly cited references

Pubmed IDYearTitleCitations
272658952016Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia.109
317237812018Advances in B-cell Precursor Acute Lymphoblastic Leukemia Genomics.21
330958732020Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia.6
312432742019Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia.5

Bibliography

Pubmed IDLast YearTitleAuthors
272658952016Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia.Lilljebjörn H et al
277761152016Deregulation of DUX4 and ERG in acute lymphoblastic leukemia.Zhang J et al

Summary

Fusion gene

IGH/DUX4 IGH (14q32.33) DUX4 (4q35.2)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Philippe Dessen ; Jean-Loup Huret

t(4;14)(q35;q32) IGH/DUX4

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2796/t(4;14)(q35;q32)-igh-dux4