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t(5;10)(q32;q21) CCDC6/PDGFRB

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2578

Clinics and Pathology

Disease Atypical chronic myeloid leukemia:Chronic eosinophilic leukemia/hypereosinophilic syndrome:Chronic myelomonocytic leukemia:Chronic myeloproliferative disorder, NOS

Genes involved and Proteins

Gene NameCCDC6
Location 10q21.2
Gene NamePDGFRB
Location 5q32

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Fusion of H4/D10S170 to the platelet-derived growth factor receptor beta in BCR-ABL-negative myeloproliferative disorders with a t(5;10)(q33;q21)
Kulkarni S, Heath C, Parker S, Chase A, Iqbal S, Pocock CF, Kaeda J, Cwynarski K, Goldman JM, Cross NC
Cancer Res 2000 Jul 1;60(13):3592-8
PMID 10910073
 
H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22)
Schwaller J, Anastasiadou E, Cain D, Kutok J, Wojiski S, Williams IR, LaStarza R, Crescenzi B, Sternberg DW, Andreasson P, Schiavo R, Siena S, Mecucci C, Gilliland DG
Blood 2001 Jun 15;97(12):3910-8
PMID 11389034
 
Fusion of H4/D10S170 to PDGFRbeta in a patient with chronic myelomonocytic leukemia and long-term responsiveness to imatinib
Drechsler M, Hildebrandt B, Kündgen A, Germing U, Royer-Pokora B
Ann Hematol 2007 May;86(5):353-4
PMID 17211520
 
Screening for diverse PDGFRA or PDGFRB fusion genes is facilitated by generic quantitative reverse transcriptase polymerase chain reaction analysis
Erben P, Gosenca D, Müller MC, Reinhard J, Score J, Del Valle F, Walz C, Mix J, Metzgeroth G, Ernst T, Haferlach C, Cross NC, Hochhaus A, Reiter A
Haematologica 2010 May;95(5):738-44
PMID 20107158
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(5;10)(q32;q21) CCDC6/PDGFRB

External links

CCDC6 (10q21.2) PDGFRB (5q32)

Mitelman databaset(5;10)(q32;q21) [Case List]    t(5;10)(q32;q21) [Transloc-MCList] CCDC6/PDGFRB [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Fri Feb 23 20:23:41 CET 2018


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