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ins(5;11)(q31;q23q23)|t(5;11)(q31;q23) KMT2A/ARHGAP26

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 3420
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute monoblastic leukemia (FAB type M5)|Acute monoblastic leukemia with differentiation (FAB type M5b)|Juvenile myelomonocytic leukemia

Genes involved and Proteins

Gene NameKMT2A
Location 11q23.3
Gene NameARHGAP26
Location 5q31.3


The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q
Borkhardt A, Bojesen S, Haas OA, Fuchs U, Bartelheimer D, Loncarevic IF, Bohle RM, Harbott J, Repp R, Jaeger U, Viehmann S, Henn T, Korth P, Scharr D, Lampert F
Proc Natl Acad Sci U S A 2000 Aug 1;97(16):9168-73
PMID 10908648
MLL/GRAF fusion in an infant acute monocytic leukemia (AML M5b) with a cytogenetically cryptic ins(5;11)(q31;q23q23)
Panagopoulos I, Kitagawa A, Isaksson M, Mörse H, Mitelman F, Johansson B
Genes Chromosomes Cancer 2004 Dec;41(4):400-4
PMID 15382263
Use of MLL/GRAF fusion mRNA for measurement of minimal residual disease during chemotherapy in an infant with acute monoblastic leukemia (AML-M5)
Wilda M, Perez AV, Bruch J, Woessmann W, Metzler M, Fuchs U, Borkhardt A
Genes Chromosomes Cancer 2005 Aug;43(4):424-6
PMID 15852479

Translocations implicated (Data extracted from papers in the Atlas)

 ins(5;11)(q31;q23q23)|t(5;11)(q31;q23) KMT2A/ARHGAP26

External links

KMT2A (11q23.3) ARHGAP26 (5q31.3)

Mitelman databaseins(5;11)(q31;q23q23)|t(5;11)(q31;q23) [Case List]    ins(5;11)(q31;q23q23)|t(5;11)(q31;q23) [Transloc-MCList] KMT2A/ARHGAP26 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Tue Mar 12 13:13:42 CET 2019

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