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t(5;14)(q32;q32) CCDC88C/PDGFRB

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 3427
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Chronic eosinophilic leukemia/hypereosinophilic syndrome|Chronic myeloproliferative disorder, NOS

Genes involved and Proteins

Gene NameCCDC88C
Location 14q32.11
Location 5q32


KIAA1509 is a novel PDGFRB fusion partner in imatinib-responsive myeloproliferative disease associated with a t(5;14)(q33;q32)
Levine RL, Wadleigh M, Sternberg DW, Wlodarska I, Galinsky I, Stone RM, DeAngelo DJ, Gilliland DG, Cools J
Leukemia 2005 Jan;19(1):27-30
PMID 15496975
Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion genes in eosinophilia-associated myeloid/lymphoid neoplasms
Gosenca D, Kellert B, Metzgeroth G, Haferlach C, Fabarius A, Schwaab J, Kneba M, Scheid C, Töpelt K, Erben P, Haferlach T, Cross NC, Hofmann WK, Seifarth W, Reiter A
Genes Chromosomes Cancer 2014 May;53(5):411-21
PMID 24772479

Translocations implicated (Data extracted from papers in the Atlas)

 t(5;14)(q32;q32) CCDC88C/PDGFRB

External links

CCDC88C (14q32.11) PDGFRB (5q32)

Mitelman databaset(5;14)(q32;q32) [Case List]    t(5;14)(q32;q32) [Transloc-MCList] CCDC88C/PDGFRB [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Tue Mar 12 13:13:45 CET 2019

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