t(5;14)(q35;q32) BCL11B/NKX2-5

2018-01-01   Jean-Loup Huret , Philippe Dessen 

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes Involved and Proteins

Gene name
BCL11B
Location
14q32.2
Gene name
NKX2-5
Location
5q35.1

Bibliography

Pubmed IDLast YearTitleAuthors
145003642003The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2).Nagel S et al
173080842007Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.Nagel S et al

Summary

Fusion gene

BCL11B/NKX2-5 BCL11B (14q32.2) NKX2-5 (5q35.1)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Jean-Loup Huret ; Philippe Dessen

t(5;14)(q35;q32) BCL11B/NKX2-5

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2537/t(5;14)(q35;q32)-bcl11b-nkx2-5