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t(5;15)(q32;q15) TP53BP1/PDGFRB

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3428
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Chronic myeloproliferative disorder, NOS

Genes involved and Proteins

Gene NameTP53BP1
Location 15q15.3
Gene NamePDGFRB
Location 5q32

Bibliography

p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder
Grand FH, Burgstaller S, Kühr T, Baxter EJ, Webersinke G, Thaler J, Chase AJ, Cross NC
Cancer Res 2004 Oct 15;64(20):7216-9
PMID 15492236
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(5;15)(q32;q15) TP53BP1/PDGFRB

External links

TP53BP1 (15q15.3) PDGFRB (5q32)

Mitelman databaset(5;15)(q32;q15) [Case List]    t(5;15)(q32;q15) [Transloc-MCList] TP53BP1/PDGFRB [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
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indexed on : Mon Jul 9 10:14:09 CEST 2018


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jlhuret@AtlasGeneticsOncology.org.