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t(5;17)(q32;q11) MYO18A/PDGFRB

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2993
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Chronic eosinophilic leukemia/hypereosinophilic syndrome|Chronic myeloproliferative disorder, special type

Genes involved and Proteins

Gene NameMYO18A
Location 17q11.2
Gene NamePDGFRB
Location 5q32

Bibliography

Identification of a MYO18A-PDGFRB fusion gene in an eosinophilia-associated atypical myeloproliferative neoplasm with a t(5;17)(q33-34;q11
Walz C, Haferlach C, Hänel A, Metzgeroth G, Erben P, Gosenca D, Hochhaus A, Cross NC, Reiter A
2) Genes Chromosomes Cancer
PMID 19006078
 
Screening for diverse PDGFRA or PDGFRB fusion genes is facilitated by generic quantitative reverse transcriptase polymerase chain reaction analysis
Erben P, Gosenca D, Müller MC, Reinhard J, Score J, Del Valle F, Walz C, Mix J, Metzgeroth G, Ernst T, Haferlach C, Cross NC, Hochhaus A, Reiter A
Haematologica 2010 May;95(5):738-44
PMID 20107158
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(5;17)(q32;q11) MYO18A/PDGFRB

External links

MYO18A (17q11.2) PDGFRB (5q32)

Mitelman databaset(5;17)(q32;q11) [Case List]    t(5;17)(q32;q11) [Transloc-MCList] MYO18A/PDGFRB [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon Jul 9 10:14:10 CEST 2018


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