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t(5;19)(q35;p13) NPM1/TYK2

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3023
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Anaplastic large cell lymphoma, cutaneous type|Subcutaneous panniculitis-like T-cell lymphoma

Genes involved and Proteins

Gene NameNPM1
Location 5q35.1
Gene NameTYK2
Location 19p13.2

Bibliography

A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders
Velusamy T, Kiel MJ, Sahasrabuddhe AA, Rolland D, Dixon CA, Bailey NG, Betz BL, Brown NA, Hristov AC, Wilcox RA, Miranda RN, Medeiros LJ, Jeon YK, Inamdar KV, Lim MS, Elenitoba-Johnson KS
Blood 2014 Dec 11;124(25):3768-71
PMID 25349176
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(5;19)(q35;p13) NPM1/TYK2

External links

NPM1 (5q35.1) TYK2 (19p13.2)

Mitelman databaset(5;19)(q35;p13) [Case List]    t(5;19)(q35;p13) [Transloc-MCList] NPM1/TYK2 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Aug 28 18:20:14 CEST 2018


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