Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(5;19)(q35;p13) NPM1::TYK2

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Atlas_Id 3023
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Anaplastic large cell lymphoma, cutaneous type|Subcutaneous panniculitis-like T-cell lymphoma

Genes involved and Proteins

Gene NameNPM1
Location 5q35.1
Gene NameTYK2
Location 19p13.2


A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders
Velusamy T, Kiel MJ, Sahasrabuddhe AA, Rolland D, Dixon CA, Bailey NG, Betz BL, Brown NA, Hristov AC, Wilcox RA, Miranda RN, Medeiros LJ, Jeon YK, Inamdar KV, Lim MS, Elenitoba-Johnson KS
Blood 2014 Dec 11;124(25):3768-71
PMID 25349176

Translocations implicated (Data extracted from papers in the Atlas)

 t(5;19)(q35;p13) NPM1/TYK2

External links

NPM1 (5q35.1) TYK2 (19p13.2)

Mitelman databaset(5;19)(q35;p13)
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Fri Oct 8 16:38:35 CEST 2021

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