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t(6;7)(q23;q36) MYB/MNX1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2984

Clinics and Pathology

Disease Acute myelomonocytic leukemia (FAB type M4)

Genes involved and Proteins

Gene NameMYB
Location 6q23.3
Gene NameMNX1
Location 7q36.3

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

Activation of HLXB9 by juxtaposition with MYB via formation of t(6;7)(q23;q36) in an AML-M4 cell line (GDM-1)
Nagel S, Kaufmann M, Scherr M, Drexler HG, MacLeod RA
Genes Chromosomes Cancer 2005 Feb;42(2):170-8
PMID 15540222
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(6;7)(q23;q36) MYB/MNX1

External links

MYB (6q23.3) MNX1 (7q36.3)

Mitelman databaset(6;7)(q23;q36) [Case List]    t(6;7)(q23;q36) [Transloc-MCList] MYB/MNX1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Fri Feb 23 20:23:54 CET 2018


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jlhuret@AtlasGeneticsOncology.org.