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t(6;8)(q27;p11) FGFR1OP/FGFR1

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3432
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Acute myeloid leukemia, NOS|Acute myelomonocytic leukemia (FAB type M4)|Chronic myeloproliferative disorder, NOS|Polycythemia vera

Genes involved and Proteins

Gene NameFGFR1OP
Location 6q27
Gene NameFGFR1
Location 8p11.23

Bibliography

Identification of four new translocations involving FGFR1 in myeloid disorders
Sohal J, Chase A, Mould S, Corcoran M, Oscier D, Iqbal S, Parker S, Welborn J, Harris RI, Martinelli G, Montefusco V, Sinclair P, Wilkins BS, van den Berg H, Vanstraelen D, Goldman JM, Cross NC
Genes Chromosomes Cancer 2001 Oct;32(2):155-63
PMID 11550283
 
Identification of four new translocations involving FGFR1 in myeloid disorders
Sohal J, Chase A, Mould S, Corcoran M, Oscier D, Iqbal S, Parker S, Welborn J, Harris RI, Martinelli G, Montefusco V, Sinclair P, Wilkins BS, van den Berg H, Vanstraelen D, Goldman JM, Cross NC
Genes Chromosomes Cancer 2001 Oct;32(2):155-63
PMID 11550283
 
The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
Popovici C, Zhang B, Grégoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pébusque MJ
Blood 1999 Feb 15;93(4):1381-9
PMID 9949182
 
Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: two further cases
Vizmanos JL, Hernández R, Vidal MJ, Larráyoz MJ, Odero MD, Marín J, Ardanaz MT, Calasanz MJ, Cross NC
Hematol J 2004;5(6):534-7
PMID 15570299
 
Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: two further cases
Vizmanos JL, Hernández R, Vidal MJ, Larráyoz MJ, Odero MD, Marín J, Ardanaz MT, Calasanz MJ, Cross NC
Hematol J 2004;5(6):534-7
PMID 15570299
 
Recurrent SPI1 (PU
Seki M, Kimura S, Isobe T, Yoshida K, Ueno H, Nakajima-Takagi Y, Wang C, Lin L, Kon A, Suzuki H, Shiozawa Y, Kataoka K, Fujii Y, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Masuda K, Kawamoto H, Ohki K, Kato M, Arakawa Y, Koh K, Hanada R, Moritake H, Akiyama M, Kobayashi R, Deguchi T, Hashii Y, Imamura T, Sato A, Kiyokawa N, Oka A, Hayashi Y, Takagi M, Manabe A, Ohara A, Horibe K, Sanada M, Iwama A, Mano H, Miyano S, Ogawa S, Takita J
1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia Nat Genet
PMID 28671687
 
The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
Popovici C, Zhang B, Grégoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pébusque MJ
Blood 1999 Feb 15;93(4):1381-9
PMID 9949182
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(6;8)(q27;p11) FGFR1OP/FGFR1

External links

FGFR1OP (6q27) FGFR1 (8p11.23)

Mitelman databaset(6;8)(q27;p11) [Case List]    t(6;8)(q27;p11) [Transloc-MCList] FGFR1OP/FGFR1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Nov 6 14:06:24 CET 2018


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