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t(6;14)(p25;q32) IGH/IRF4

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2802
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Diffuse large B-cell lymphoma|Follicular lymphoma|Multiple myeloma

Genes involved and Proteins

Gene NameIGH
Location 14q32.33
Gene NameIRF4

Bibliography

Detection of MUM1/IRF4-IgH fusion in multiple myeloma
Yoshida S, Nakazawa N, Iida S, Hayami Y, Sato S, Wakita A, Shimizu S, Taniwaki M, Ueda R
Leukemia 1999 Nov;13(11):1812-6
PMID 10557056
 
Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
Iida S, Rao PH, Butler M, Corradini P, Boccadoro M, Klein B, Chaganti RS, Dalla-Favera R
Nat Genet 1997 Oct;17(2):226-30
PMID 9326949
 
Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults
Salaverria I, Philipp C, Oschlies I, Kohler CW, Kreuz M, Szczepanowski M, Burkhardt B, Trautmann H, Gesk S, Andrusiewicz M, Berger H, Fey M, Harder L, Hasenclever D, Hummel M, Loeffler M, Mahn F, Martin-Guerrero I, Pellissery S, Pott C, Pfreundschuh M, Reiter A, Richter J, Rosolowski M, Schwaenen C, Stein H, Trümper L, Wessendorf S, Spang R, Küppers R, Klapper W, Siebert R; Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe; German High-Grade Lymphoma Study Group; Berlin-Frankfurt-Münster-NHL trial group
Blood 2011 Jul 7;118(1):139-47
PMID 21487109
 
Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults
Salaverria I, Philipp C, Oschlies I, Kohler CW, Kreuz M, Szczepanowski M, Burkhardt B, Trautmann H, Gesk S, Andrusiewicz M, Berger H, Fey M, Harder L, Hasenclever D, Hummel M, Loeffler M, Mahn F, Martin-Guerrero I, Pellissery S, Pott C, Pfreundschuh M, Reiter A, Richter J, Rosolowski M, Schwaenen C, Stein H, Trümper L, Wessendorf S, Spang R, Küppers R, Klapper W, Siebert R; Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe; German High-Grade Lymphoma Study Group; Berlin-Frankfurt-Münster-NHL trial group
Blood 2011 Jul 7;118(1):139-47
PMID 21487109
 
Novel IGH and MYC Translocation Partners in Diffuse Large B-Cell Lymphomas
Otto C, Scholtysik R, Schmitz R, Kreuz M, Becher C, Hummel M, Rosenwald A, Trümper L, Klapper W, Siebert R, Küppers R; “Molecular Mechanisms in Malignant Lymphomas” Network Project
Genes Chromosomes Cancer 2016 Dec;55(12):932-943
PMID 27356265
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(6;14)(p25;q32) IGH/IRF4

External links

IGH (14q32.33) IRF4 ()

Mitelman databaset(6;14)(p25;q32) [Case List]    t(6;14)(p25;q32) [Transloc-MCList] IGH/IRF4 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon May 14 13:43:23 CEST 2018


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