Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(7;8)(q22;p11) FGFR1/CUX1

Written2018-01Jean-Loup Huret, Philippe Dessen

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Atlas_Id 1583

Clinics and Pathology

Disease -

Genes involved and Proteins

Gene NameFGFR1
Location 8p11.23
Gene NameCUX1
Location 7q22.1

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute


FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review)
Katoh M
Int J Mol Med 2016 Jul;38(1):3-15
PMID 27245147
The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11)
Wasag B, Lierman E, Meeus P, Cools J, Vandenberghe P
Haematologica 2011 Jun;96(6):922-6
PMID 21330321

Translocations implicated (Data extracted from papers in the Atlas)

 t(7;8)(q22;p11) FGFR1/CUX1

External links

FGFR1 (8p11.23) CUX1 (7q22.1)

Mitelman databaset(7;8)(q22;p11) [Case List]    t(7;8)(q22;p11) [Transloc-MCList] FGFR1/CUX1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Jan 10 17:21:48 CET 2018

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