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t(7;9)(q34;q31) TRB/TAL2

Written2018-01Jean-Loup Huret, Philippe Dessen

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Atlas_Id 3436
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma|Nonneoplastic hematologic disorder/lesion

Genes involved and Proteins

Gene NameTRB
Location 7q34
Gene NameTAL2
Location 9q31.2


Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL
Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B
Nat Genet 2003 Mar;33(3):342-4
PMID 12567187
TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia
Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R 3rd, Le Beau MM, Baer RJ
Proc Natl Acad Sci U S A 1991 Dec 15;88(24):11416-20
PMID 1763056
Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity
Xia Y, Hwang LY, Cobb MH, Baer R
Oncogene 1994 May;9(5):1437-46
PMID 8152805

Translocations implicated (Data extracted from papers in the Atlas)

 t(7;9)(q34;q31) TRB/TAL2

External links

TRB (7q34) TAL2 (9q31.2)

Mitelman databaset(7;9)(q34;q31) [Case List]    t(7;9)(q34;q31) [Transloc-MCList] TRB/TAL2 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Tue Mar 12 13:14:06 CET 2019

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