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t(7;11)(p15;p15) NUP98/HOXA11

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3037
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute myeloblastic leukemia with maturation (FAB type M2)|Chronic myeloid leukemia, t(9;22)|Juvenile myelomonocytic leukemia

Genes involved and Proteins

Gene NameNUP98
Location 11p15.4
Gene NameHOXA11
Location 7p15.2

Bibliography

Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)
Fujino T, Suzuki A, Ito Y, Ohyashiki K, Hatano Y, Miura I, Nakamura T
Blood 2002 Feb 15;99(4):1428-33
PMID 11830496
 
t(7;11)(p15;p15) Chronic myeloid leukaemia developed into blastic transformation showing a novel NUP98/HOXA11 fusion
Suzuki A, Ito Y, Sashida G, Honda S, Katagiri T, Fujino T, Nakamura T, Ohyashiki K
Br J Haematol 2002 Jan;116(1):170-2
PMID 11841413
 
Juvenile myelomonocytic leukemia with t(7;11)(p15;p15) and NUP98-HOXA11 fusion
Mizoguchi Y, Fujita N, Taki T, Hayashi Y, Hamamoto K
Am J Hematol 2009 May;84(5):295-7
PMID 19338047
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(7;11)(p15;p15) NUP98/HOXA11

External links

NUP98 (11p15.4) HOXA11 (7p15.2)

Mitelman databaset(7;11)(p15;p15) [Case List]    t(7;11)(p15;p15) [Transloc-MCList] NUP98/HOXA11 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Mon May 14 13:43:37 CEST 2018


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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.