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t(7;11)(p15;p15) NUP98/HOXA11

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 3037

Clinics and Pathology

Disease Acute myeloblastic leukemia with maturation (FAB type M2):Chronic myeloid leukemia, t(9;22):Juvenile myelomonocytic leukemia

Genes involved and Proteins

Gene NameNUP98
Location 11p15.4
Gene NameHOXA11
Location 7p15.2

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute


Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11)(p15;p15)
Yamamoto K, Nakamura Y, Saito K, Furusawa S
Br J Haematol 2000 May;109(2):423-6
PMID 10848835
NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia
Ahuja HG, Popplewell L, Tcheurekdjian L, Slovak ML
Genes Chromosomes Cancer 2001 Apr;30(4):410-5
PMID 11241795
Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)
Fujino T, Suzuki A, Ito Y, Ohyashiki K, Hatano Y, Miura I, Nakamura T
Blood 2002 Feb 15;99(4):1428-33
PMID 11830496
t(7;11)(p15;p15) Chronic myeloid leukaemia developed into blastic transformation showing a novel NUP98/HOXA11 fusion
Suzuki A, Ito Y, Sashida G, Honda S, Katagiri T, Fujino T, Nakamura T, Ohyashiki K
Br J Haematol 2002 Jan;116(1):170-2
PMID 11841413
The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9
Taketani T, Taki T, Ono R, Kobayashi Y, Ida K, Hayashi Y
Genes Chromosomes Cancer 2002 Aug;34(4):437-43
PMID 12112533
Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, Chen SJ, Willman CL, Chen IM, Feinberg AP, Jenkins NA, Copeland NG, Shaughnessy JD Jr
Nat Genet 1996 Feb;12(2):154-8
PMID 8563753
Clinical, haematological and molecular studies in patients with chromosome translocation t(7;11): a study of four Chinese patients in Taiwan
Huang SY, Tang JL, Liang YJ, Wang CH, Chen YC, Tien HF
Br J Haematol 1997 Mar;96(4):682-7
PMID 9074407
Juvenile myelomonocytic leukemia with t(7;11)(p15;p15) and NUP98-HOXA11 fusion
Mizoguchi Y, Fujita N, Taki T, Hayashi Y, Hamamoto K
Am J Hematol 2009 May;84(5):295-7
PMID 19338047

Translocations implicated (Data extracted from papers in the Atlas)

 t(7;11)(p15;p15) NUP98/HOXA11

External links

NUP98 (11p15.4) HOXA11 (7p15.2)

Mitelman databaset(7;11)(p15;p15) [Case List]    t(7;11)(p15;p15) [Transloc-MCList] NUP98/HOXA11 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Jan 10 17:21:50 CET 2018

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