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t(7;11)(q21;q23) CDK6/KMT2A

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2587
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameCDK6
Location 7q21.2
Gene NameKMT2A
Location 11q23.3

Bibliography

Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6
Raffini LJ, Slater DJ, Rappaport EF, Lo Nigro L, Cheung NK, Biegel JA, Nowell PC, Lange BJ, Felix CA
Proc Natl Acad Sci U S A 2002 Apr 2;99(7):4568-73
PMID 11930009
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(7;11)(q21;q23) CDK6/KMT2A

External links

CDK6 (7q21.2) KMT2A (11q23.3)

Mitelman databaset(7;11)(q21;q23) [Case List]    t(7;11)(q21;q23) [Transloc-MCList] CDK6/KMT2A [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Tue Nov 6 14:06:45 CET 2018


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jlhuret@AtlasGeneticsOncology.org.