t(7;11)(q21;q23) CDK6/KMT2A

Identity

ICD-Topo	C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id	2587
Note	Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease

Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene Name	CDK6
Location	7q21.2

Gene Name	KMT2A
Location	11q23.3

Bibliography

Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6

Raffini LJ, Slater DJ, Rappaport EF, Lo Nigro L, Cheung NK, Biegel JA, Nowell PC, Lange BJ, Felix CA

Proc Natl Acad Sci U S A 2002 Apr 2;99(7):4568-73

PMID 11930009

Translocations implicated (Data extracted from papers in the Atlas)

	t(7;11)(q21;q23) CDK6/KMT2A

External links

CDK6 (7q21.2) KMT2A (11q23.3)

Mitelman database	t(7;11)(q21;q23) [Case List]    t(7;11)(q21;q23) [Transloc-MCList] CDK6/KMT2A [Fusion-MCList]
COSMIC	Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)	[select an item]

REVIEW articles	automatic search in PubMed
Last year articles	automatic search in PubMed
All articles	automatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Nov 28 16:22:04 CET 2018

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