| Identity |
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| Atlas_Id | 2587 |
| Note | Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to How to contribute |
| Clinics and Pathology |
| Disease | Acute lymphoblastic leukemia/lymphoblastic lymphoma |
| Genes involved and Proteins |
| Gene Name | CDK6 |
| Location | 7q21.2 |
| Gene Name | KMT2A |
| Location | 11q23.3 |
| Bibliography |
| Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6 |
| Raffini LJ, Slater DJ, Rappaport EF, Lo Nigro L, Cheung NK, Biegel JA, Nowell PC, Lange BJ, Felix CA |
| Proc Natl Acad Sci U S A 2002 Apr 2;99(7):4568-73 |
| PMID 11930009 |
| Translocations implicated (Data extracted from papers in the Atlas) |
| t(7;11)(q21;q23) CDK6/KMT2A | |
| External links |
| Mitelman database | t(7;11)(q21;q23) |
| COSMIC | Histo = - Site = haematopoietic_and_lymphoid_tissue (COSMIC) |
| arrayMap (UZH-SIB Zurich) | [select an item] |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Dec 14 18:28:03 CET 2020 |
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