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t(8;11)(p12;p15) NUP98/NSD3

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3040

Clinics and Pathology

Disease Acute myeloblastic leukemia without maturation (FAB type M1):Acute myeloid leukemia, NOS

Genes involved and Proteins

Gene NameNUP98
Location 11p15.4
Gene NameNSD3
Location 8p11.23

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute

Bibliography

NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11
Rosati R, La Starza R, Veronese A, Aventin A, Schwienbacher C, Vallespi T, Negrini M, Martelli MF, Mecucci C
2;p15) Blood
PMID 11986249
 
NUP98-NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8;11)(p11;p15) and expression pattern of NSD family genes
Taketani T, Taki T, Nakamura H, Taniwaki M, Masuda J, Hayashi Y
Cancer Genet Cytogenet 2009 Apr 15;190(2):108-12
PMID 19380029
 


Translocations implicated (Data extracted from papers in the Atlas)

 t(8;11)(p12;p15) NUP98/NSD3

External links

NUP98 (11p15.4) NSD3 (8p11.23)

Mitelman databaset(8;11)(p12;p15) [Case List]    t(8;11)(p12;p15) [Transloc-MCList] NUP98/NSD3 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


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indexed on : Wed Jan 10 17:22:00 CET 2018


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