Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

t(8;14)(q24;q11) TRD/MYC

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 3294

Clinics and Pathology

Disease Acute lymphoblastic leukemia/lymphoblastic lymphoma

Genes involved and Proteins

Gene NameTRD
Location 10p13
Gene NameMYC
Location 14q23.3

To be noted

Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on the chromosome abnormality, go to  How to contribute


Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation
Kasai M, Maziarz RT, Aoki K, Macintyre E, Strominger JL
Mol Cell Biol 1992 Oct;12(10):4751-7
PMID 1406658
Growth factor requirements of childhood acute T-lymphoblastic leukemia: correlation between presence of chromosomal abnormalities and ability to grow permanently in vitro
O'Connor R, Cesano A, Lange B, Finan J, Nowell PC, Clark SC, Raimondi SC, Rovera G, Santoli D
Blood 1991 Apr 1;77(7):1534-45
PMID 1706955
Extensive molecular mapping of TCRα/δ- and TCRβ-involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL
Le Noir S, Ben Abdelali R, Lelorch M, Bergeron J, Sungalee S, Payet-Bornet D, Villarèse P, Petit A, Callens C, Lhermitte L, Baranger L, Radford-Weiss I, Grégoire MJ, Dombret H, Ifrah N, Spicuglia S, Romana S, Soulier J, Nadel B, Macintyre E, Asnafi V
Blood 2012 Oct 18;120(16):3298-309
PMID 22948044
A t(8;14)(q24;q11) translocation in a T-cell leukemia (L1-ALL) with c-myc and TcR-alpha chain locus rearrangements
Mathieu-Mahul D, Sigaux F, Zhu C, Bernheim A, Mauchauffe M, Daniel MT, Berger R, Larsen CJ
Int J Cancer 1986 Dec 15;38(6):835-40
PMID 3466870
T-cell acute lymphoblastic leukemias with a t(8;14) possibly involving a c-myc locus and T-cell-receptor alpha-chain genes
Hayashi Y, Yamamoto K, Kojima S
N Engl J Med 1986 Mar 6;314(10):650-1
PMID 3484803
Deregulation of c-myc by translocation of the alpha-locus of the T-cell receptor in T-cell leukemias
Erikson J, Finger L, Sun L, ar-Rushdi A, Nishikura K, Minowada J, Finan J, Emanuel BS, Nowell PC, Croce CM
Science 1986 May 16;232(4752):884-6
PMID 3486470
A common mechanism of chromosomal translocation in T- and B-cell neoplasia
Finger LR, Harvey RC, Moore RC, Showe LC, Croce CM
Science 1986 Nov 21;234(4779):982-5
PMID 3490692
Molecular cloning of the breakpoint junction of a human chromosomal 8;14 translocation involving the T-cell receptor alpha-chain gene and sequences on the 3' side of MYC
McKeithan TW, Shima EA, Le Beau MM, Minowada J, Rowley JD, Diaz MO
Proc Natl Acad Sci U S A 1986 Sep;83(17):6636-40
PMID 3529089

Translocations implicated (Data extracted from papers in the Atlas)

 t(8;14)(q24;q11) TRD/MYC

External links

TRD (10p13) MYC (14q23.3)

Mitelman databaset(8;14)(q24;q11) [Case List]    t(8;14)(q24;q11) [Transloc-MCList] TRD/MYC [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jan 10 17:22:01 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us